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Antifungal chalcones from Maclura tinctoria.
Planta Med. 2001 Feb; 67(1):87-9.PM

Abstract

Five prenylated flavonoids, including one new natural product, were isolated from an ethanol extract of the leaves of Maclura tinctoria (L.) Gaud. The new compound has been characterized as 2',4',4,2''-tetrahydroxy-3'-[3''-methylbut-3''-enyl]chalcone (1). The known compounds were identified as 2',4',4-trihydroxy-3'-[3''-methylbut-3''-enyl]chalcone (isobavachalcone) (2), 4,2'-dihydroxy-2''-[1-hydroxy-1-methylethyl]-2'',3''-dihydrofurano[4'',5'':3',4']chalcone (bakuchalcone) (3), 4,4',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3'':5',6'']chalcone (bavachromanol) (4), and 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (6,8-diprenylorobol) (5). All the isolated compounds were evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. Compound 2 was active against both yeasts.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Letter
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11270732

Citation

ElSohly, H N., et al. "Antifungal Chalcones From Maclura Tinctoria." Planta Medica, vol. 67, no. 1, 2001, pp. 87-9.
ElSohly HN, Joshi AS, Nimrod AC, et al. Antifungal chalcones from Maclura tinctoria. Planta Med. 2001;67(1):87-9.
ElSohly, H. N., Joshi, A. S., Nimrod, A. C., Walker, L. A., & Clark, A. M. (2001). Antifungal chalcones from Maclura tinctoria. Planta Medica, 67(1), 87-9.
ElSohly HN, et al. Antifungal Chalcones From Maclura Tinctoria. Planta Med. 2001;67(1):87-9. PubMed PMID: 11270732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal chalcones from Maclura tinctoria. AU - ElSohly,H N, AU - Joshi,A S, AU - Nimrod,A C, AU - Walker,L A, AU - Clark,A M, PY - 2001/3/29/pubmed PY - 2001/7/13/medline PY - 2001/3/29/entrez SP - 87 EP - 9 JF - Planta medica JO - Planta Med VL - 67 IS - 1 N2 - Five prenylated flavonoids, including one new natural product, were isolated from an ethanol extract of the leaves of Maclura tinctoria (L.) Gaud. The new compound has been characterized as 2',4',4,2''-tetrahydroxy-3'-[3''-methylbut-3''-enyl]chalcone (1). The known compounds were identified as 2',4',4-trihydroxy-3'-[3''-methylbut-3''-enyl]chalcone (isobavachalcone) (2), 4,2'-dihydroxy-2''-[1-hydroxy-1-methylethyl]-2'',3''-dihydrofurano[4'',5'':3',4']chalcone (bakuchalcone) (3), 4,4',5''-trihydroxy-6'',6''-dimethyldihydropyrano[2'',3'':5',6'']chalcone (bavachromanol) (4), and 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (6,8-diprenylorobol) (5). All the isolated compounds were evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. Compound 2 was active against both yeasts. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/11270732/Antifungal_chalcones_from_Maclura_tinctoria_ L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-10621 DB - PRIME DP - Unbound Medicine ER -