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Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells.
Zhongguo Yao Li Xue Bao. 1999 Nov; 20(11):1015-8.ZY

Abstract

AIM

To elucidate whether or not changrolin (CRL) modifies the potassium currents (ITO, IK, and IKl) in myocardial cells.

METHODS

A tight seal whole-cell patch-clamp technique was used to record ITO, IK, and IKl in single cells isolated from guinea pig and rabbit hearts.

RESULTS

At a clinically relevant concentration, CRL 50 mumol.L-1 inhibited the transient outward current (ITO) by 17.7% +/- 2.4% (n = 8) in rabbit atrial cells. The voltage-dependence of steady-state inactivation of ITO was not affected by CRL. This concentration of CRL did not influence the time-independent inward rectifier or the delayed rectifier K+ currents (IKl and IK, respectively) in rabbit and guinea pig ventricular cells.

CONCLUSION

CRL inhibited ITO, but not IK nor IKl.

Authors+Show Affiliations

Department of Physiology, College of Medicine, Xiamen University, Xiamen 361005, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11270967

Citation

Lü, L L.. "Effects of Changrolin On Potassium Currents in Guinea Pig and Rabbit Single Heart Cells." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 20, no. 11, 1999, pp. 1015-8.
Lü LL. Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells. Zhongguo Yao Li Xue Bao. 1999;20(11):1015-8.
Lü, L. L. (1999). Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 20(11), 1015-8.
Lü LL. Effects of Changrolin On Potassium Currents in Guinea Pig and Rabbit Single Heart Cells. Zhongguo Yao Li Xue Bao. 1999;20(11):1015-8. PubMed PMID: 11270967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of changrolin on potassium currents in guinea pig and rabbit single heart cells. A1 - Lü,L L, PY - 2001/3/29/pubmed PY - 2001/4/3/medline PY - 2001/3/29/entrez SP - 1015 EP - 8 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 20 IS - 11 N2 - AIM: To elucidate whether or not changrolin (CRL) modifies the potassium currents (ITO, IK, and IKl) in myocardial cells. METHODS: A tight seal whole-cell patch-clamp technique was used to record ITO, IK, and IKl in single cells isolated from guinea pig and rabbit hearts. RESULTS: At a clinically relevant concentration, CRL 50 mumol.L-1 inhibited the transient outward current (ITO) by 17.7% +/- 2.4% (n = 8) in rabbit atrial cells. The voltage-dependence of steady-state inactivation of ITO was not affected by CRL. This concentration of CRL did not influence the time-independent inward rectifier or the delayed rectifier K+ currents (IKl and IK, respectively) in rabbit and guinea pig ventricular cells. CONCLUSION: CRL inhibited ITO, but not IK nor IKl. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/11270967/Effects_of_changrolin_on_potassium_currents_in_guinea_pig_and_rabbit_single_heart_cells_ L2 - http://www.chinaphar.com/1671-4083/20/1015.pdf DB - PRIME DP - Unbound Medicine ER -