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Is brachytherapy comparable with radical prostatectomy and external-beam radiation for clinically localized prostate cancer?
Tech Urol 2001; 7(1):12-9TU

Abstract

PURPOSE

The aim of this study was to summarize the prostate brachytherapy literature and provide a comparative analysis of brachytherapy, radical prostatectomy, and external-beam radiation therapy outcomes for early-stage carcinoma of the prostate gland.

MATERIALS AND METHODS

Published literature on brachytherapy, radical prostatectomy, and external-beam radiation therapy for clinically localized carcinoma ofthe prostate gland was reviewed. In addition, MEDLINE searches were performed to ensure completeness of the knowledge base.

RESULTS

For patients with low-risk features, the biochemical results of prostate brachytherapy are as favorable as the most positive radical prostatectomy and external-beam radiation therapy series. In most studies, patients with intermediate- and high-risk disease have more durable biochemical outcomes when treated with brachytherapy (with or without external-beam radiation therapy). Long-term urinary morbidity is primarily restricted to patients with a history of transurethral resection. Significant bowel dysfunction is uncommon. Although erectile dysfunction occurs in approximately 50% of patients at 5 years, 80% respond favorably to sildenafil. Multiple postoperative dosimetric studies supported the ability of brachytherapists to adequately encompass the target volume. Compared with radical prostatectomy and external-beam radiation therapy, the total cost of prostate brachytherapy is 20% less.

CONCLUSIONS

With prostate-specific antigen-based follow-up as long as 10 years, the results of prostate brachytherapy for low-risk patients are as favorable as the most positive radical prostatectomy and external-beam radiation therapy series. In most reports, intermediate- and high-risk patients have more durable biochemical outcomes when managed by brachytherapy approach (with or without external-beam radiation therapy). Serious complications following brachytherapy are relatively rare.

Authors+Show Affiliations

Schiffler Cancer Center, Wheeling Hospital, West Virginia 26033-6300, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

11272667

Citation

Merrick, G S., et al. "Is Brachytherapy Comparable With Radical Prostatectomy and External-beam Radiation for Clinically Localized Prostate Cancer?" Techniques in Urology, vol. 7, no. 1, 2001, pp. 12-9.
Merrick GS, Butler WM, Lief JH, et al. Is brachytherapy comparable with radical prostatectomy and external-beam radiation for clinically localized prostate cancer? Tech Urol. 2001;7(1):12-9.
Merrick, G. S., Butler, W. M., Lief, J. H., & Dorsey, A. T. (2001). Is brachytherapy comparable with radical prostatectomy and external-beam radiation for clinically localized prostate cancer? Techniques in Urology, 7(1), pp. 12-9.
Merrick GS, et al. Is Brachytherapy Comparable With Radical Prostatectomy and External-beam Radiation for Clinically Localized Prostate Cancer. Tech Urol. 2001;7(1):12-9. PubMed PMID: 11272667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is brachytherapy comparable with radical prostatectomy and external-beam radiation for clinically localized prostate cancer? AU - Merrick,G S, AU - Butler,W M, AU - Lief,J H, AU - Dorsey,A T, PY - 2001/3/29/pubmed PY - 2001/7/6/medline PY - 2001/3/29/entrez SP - 12 EP - 9 JF - Techniques in urology JO - Tech Urol VL - 7 IS - 1 N2 - PURPOSE: The aim of this study was to summarize the prostate brachytherapy literature and provide a comparative analysis of brachytherapy, radical prostatectomy, and external-beam radiation therapy outcomes for early-stage carcinoma of the prostate gland. MATERIALS AND METHODS: Published literature on brachytherapy, radical prostatectomy, and external-beam radiation therapy for clinically localized carcinoma ofthe prostate gland was reviewed. In addition, MEDLINE searches were performed to ensure completeness of the knowledge base. RESULTS: For patients with low-risk features, the biochemical results of prostate brachytherapy are as favorable as the most positive radical prostatectomy and external-beam radiation therapy series. In most studies, patients with intermediate- and high-risk disease have more durable biochemical outcomes when treated with brachytherapy (with or without external-beam radiation therapy). Long-term urinary morbidity is primarily restricted to patients with a history of transurethral resection. Significant bowel dysfunction is uncommon. Although erectile dysfunction occurs in approximately 50% of patients at 5 years, 80% respond favorably to sildenafil. Multiple postoperative dosimetric studies supported the ability of brachytherapists to adequately encompass the target volume. Compared with radical prostatectomy and external-beam radiation therapy, the total cost of prostate brachytherapy is 20% less. CONCLUSIONS: With prostate-specific antigen-based follow-up as long as 10 years, the results of prostate brachytherapy for low-risk patients are as favorable as the most positive radical prostatectomy and external-beam radiation therapy series. In most reports, intermediate- and high-risk patients have more durable biochemical outcomes when managed by brachytherapy approach (with or without external-beam radiation therapy). Serious complications following brachytherapy are relatively rare. SN - 1079-3259 UR - https://www.unboundmedicine.com/medline/citation/11272667/Is_brachytherapy_comparable_with_radical_prostatectomy_and_external_beam_radiation_for_clinically_localized_prostate_cancer L2 - http://www.diseaseinfosearch.org/result/9175 DB - PRIME DP - Unbound Medicine ER -