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Association of HLA B27 antigen in Indian patients of ankylosing spondylitis and other autoimmune diseases.
J Assoc Physicians India. 1998 Apr; 46(4):345-50.JA

Abstract

One thousand three hundred and forty clinically suspected patients of Ankylosing Spondylitis (AS) and other autoimmune diseases and 5000 controls were studied to detect the association of HLA B27 antigen amongst them. Other alleles studied include HLA B7, B40 (B60), B22(B55), B13, etc. Our findings show a considerable and consistent association of HLA B27 with AS irrespective of the community to which the patient, belonged his hygiene or socio-economic conditions. We also found that people in the age group of 21-39 were the most vulnerable, when number of affected individuals or severity of the disease were taken into consideration. Male members showed a preponderance over females in HLA B27 positivity. Detection of HLA B27 could help in the diagnosis of AS. Patients suffering from other autoimmune diseases such as rheumatoid arthritis, psoriasis, Reiter's syndrome and uveitis and patients with inflammatory bowel disease, colitis, eczema, bacillary or fungal infection were also found to be HLA B27 positive. A study of other alleles shows that even they sometimes associate AS and other autoimmune diseases.

Authors+Show Affiliations

Tissue Typing Laboratory, Medical Research Center and Post Graduate Institute of Medical Sciences, Bombay Hospital, Mumbai 400 020.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11273314

Citation

Kankonkar, S R., et al. "Association of HLA B27 Antigen in Indian Patients of Ankylosing Spondylitis and Other Autoimmune Diseases." The Journal of the Association of Physicians of India, vol. 46, no. 4, 1998, pp. 345-50.
Kankonkar SR, Raikar SC, Joshi SV, et al. Association of HLA B27 antigen in Indian patients of ankylosing spondylitis and other autoimmune diseases. J Assoc Physicians India. 1998;46(4):345-50.
Kankonkar, S. R., Raikar, S. C., Joshi, S. V., & Tijoriwala, S. J. (1998). Association of HLA B27 antigen in Indian patients of ankylosing spondylitis and other autoimmune diseases. The Journal of the Association of Physicians of India, 46(4), 345-50.
Kankonkar SR, et al. Association of HLA B27 Antigen in Indian Patients of Ankylosing Spondylitis and Other Autoimmune Diseases. J Assoc Physicians India. 1998;46(4):345-50. PubMed PMID: 11273314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of HLA B27 antigen in Indian patients of ankylosing spondylitis and other autoimmune diseases. AU - Kankonkar,S R, AU - Raikar,S C, AU - Joshi,S V, AU - Tijoriwala,S J, PY - 2001/3/29/pubmed PY - 2001/4/6/medline PY - 2001/3/29/entrez SP - 345 EP - 50 JF - The Journal of the Association of Physicians of India JO - J Assoc Physicians India VL - 46 IS - 4 N2 - One thousand three hundred and forty clinically suspected patients of Ankylosing Spondylitis (AS) and other autoimmune diseases and 5000 controls were studied to detect the association of HLA B27 antigen amongst them. Other alleles studied include HLA B7, B40 (B60), B22(B55), B13, etc. Our findings show a considerable and consistent association of HLA B27 with AS irrespective of the community to which the patient, belonged his hygiene or socio-economic conditions. We also found that people in the age group of 21-39 were the most vulnerable, when number of affected individuals or severity of the disease were taken into consideration. Male members showed a preponderance over females in HLA B27 positivity. Detection of HLA B27 could help in the diagnosis of AS. Patients suffering from other autoimmune diseases such as rheumatoid arthritis, psoriasis, Reiter's syndrome and uveitis and patients with inflammatory bowel disease, colitis, eczema, bacillary or fungal infection were also found to be HLA B27 positive. A study of other alleles shows that even they sometimes associate AS and other autoimmune diseases. SN - 0004-5772 UR - https://www.unboundmedicine.com/medline/citation/11273314/Association_of_HLA_B27_antigen_in_Indian_patients_of_ankylosing_spondylitis_and_other_autoimmune_diseases_ L2 - https://www.diseaseinfosearch.org/result/9679 DB - PRIME DP - Unbound Medicine ER -