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Loss of heterozygosity on chromosome arm 11q in lung carcinoids.
Hum Pathol. 2001 Mar; 32(3):333-8.HP

Abstract

Neuroendocrine lung tumors such as typical carcinoid, atypical carcinoid, small-cell lung carcinoma, and large-cell neuroendocrine carcinoma represent a variable group with different biologic characteristics and unclear genetical relationships. We investigated the pattern of allelic loss on chromosome arm 11q in 20 sporadic carcinoid tumors of the lung using 10 microsatellite markers. Loss of heterozygosity was found in 13 of 20 tumors. In 5 of 9 typical carcinoids, 3 distinct regions of allelic loss were identified: 11q13.1 (D11S1883), 11q14.3-11q21 (D11S906), and 11q25 (D11S910). Atypical carcinoids showed loss of heterozygosity at 4 different regions: the first, most proximal region at 11q13 between markers PYGM and D11S937; the second at 11q14.3-11q21 (D11S906); and the third and fourth defined by markers D11S939 (11q23.2-23.3) and D11S910 (11q25). However, the region 11q13 harboring the MEN1 gene was more frequently affected in atypical carcinoids (7 of 11) than in typical carcinoids (2 of 9). The high rate of allelic losses within chromosomal region 11q13 in atypical carcinoids emphasizes the importance of this region for tumor development. We also recognized that more aggressive atypical carcinoids defined by high mitotic counts, vascular invasion, and/or organ metastasis are combined with increased allelic losses. HUM PATHOL 32:333-338.

Authors+Show Affiliations

Institute of Pathology, Laboratory Environmental and Respiraory Pathology, University of Graz, Medical School, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11274644

Citation

Petzmann, S, et al. "Loss of Heterozygosity On Chromosome Arm 11q in Lung Carcinoids." Human Pathology, vol. 32, no. 3, 2001, pp. 333-8.
Petzmann S, Ullmann R, Klemen H, et al. Loss of heterozygosity on chromosome arm 11q in lung carcinoids. Hum Pathol. 2001;32(3):333-8.
Petzmann, S., Ullmann, R., Klemen, H., Renner, H., & Popper, H. H. (2001). Loss of heterozygosity on chromosome arm 11q in lung carcinoids. Human Pathology, 32(3), 333-8.
Petzmann S, et al. Loss of Heterozygosity On Chromosome Arm 11q in Lung Carcinoids. Hum Pathol. 2001;32(3):333-8. PubMed PMID: 11274644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Loss of heterozygosity on chromosome arm 11q in lung carcinoids. AU - Petzmann,S, AU - Ullmann,R, AU - Klemen,H, AU - Renner,H, AU - Popper,H H, PY - 2001/3/29/pubmed PY - 2001/5/1/medline PY - 2001/3/29/entrez SP - 333 EP - 8 JF - Human pathology JO - Hum Pathol VL - 32 IS - 3 N2 - Neuroendocrine lung tumors such as typical carcinoid, atypical carcinoid, small-cell lung carcinoma, and large-cell neuroendocrine carcinoma represent a variable group with different biologic characteristics and unclear genetical relationships. We investigated the pattern of allelic loss on chromosome arm 11q in 20 sporadic carcinoid tumors of the lung using 10 microsatellite markers. Loss of heterozygosity was found in 13 of 20 tumors. In 5 of 9 typical carcinoids, 3 distinct regions of allelic loss were identified: 11q13.1 (D11S1883), 11q14.3-11q21 (D11S906), and 11q25 (D11S910). Atypical carcinoids showed loss of heterozygosity at 4 different regions: the first, most proximal region at 11q13 between markers PYGM and D11S937; the second at 11q14.3-11q21 (D11S906); and the third and fourth defined by markers D11S939 (11q23.2-23.3) and D11S910 (11q25). However, the region 11q13 harboring the MEN1 gene was more frequently affected in atypical carcinoids (7 of 11) than in typical carcinoids (2 of 9). The high rate of allelic losses within chromosomal region 11q13 in atypical carcinoids emphasizes the importance of this region for tumor development. We also recognized that more aggressive atypical carcinoids defined by high mitotic counts, vascular invasion, and/or organ metastasis are combined with increased allelic losses. HUM PATHOL 32:333-338. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/11274644/Loss_of_heterozygosity_on_chromosome_arm_11q_in_lung_carcinoids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(01)47889-0 DB - PRIME DP - Unbound Medicine ER -