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First endoscopic-histologic follow-up in patients with body-predominant atrophic gastritis: when should it be done?
Gastrointest Endosc. 2001 Apr; 53(4):443-8.GE

Abstract

BACKGROUND

Body-predominant atrophic gastritis is considered a risk factor for gastric cancer and carcinoid. Timing of follow-up for patients with this disorder has not been defined. This study was undertaken to determine the optimal time for the first endoscopic/histologic follow-up in patients with body-predominant atrophic gastritis.

METHODS

Forty-two patients with body-predominant atrophic gastritis were randomly assigned to 1 of 2 follow-up intervals: group A (n = 22) at 24 months and group B (n = 20) at 48 months. At baseline and follow-up patients underwent gastroscopy at which biopsies were obtained from the antrum and body for histopathology and evaluation for enterochromaffin-like cells.

RESULTS

In group A patients, 2 antral hyperplastic polyps (9.1%) were present at baseline and 4 antral hyperplastic polyps (18.2%) were found at follow-up. In group B patients, baseline gastroscopy revealed 2 antral hyperplastic polyps (10%) and follow-up 2 antral hyperplastic polyps (10%) and 1 carcinoid tumor (5%) in the body. Atrophy and intestinal metaplasia scores in gastric body and antral mucosa in both groups did not change significantly between baseline and follow-up, except an increase in antral mucosa atrophy in group B patients (p = 0.02) was revealed.

CONCLUSIONS

The results of this study indicate that performing the first follow-up in patients with body-predominant atrophic gastritis need not be earlier than at 4 years after diagnosis. This interval is satisfactory for detection of potential neoplastic lesions.

Authors+Show Affiliations

Department of Gastroenterology, II Clinica Medica, Policlinico Umberto I, University "La Sapienza," Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11275884

Citation

Lahner, E, et al. "First Endoscopic-histologic Follow-up in Patients With Body-predominant Atrophic Gastritis: when Should It Be Done?" Gastrointestinal Endoscopy, vol. 53, no. 4, 2001, pp. 443-8.
Lahner E, Caruana P, D'Ambra G, et al. First endoscopic-histologic follow-up in patients with body-predominant atrophic gastritis: when should it be done? Gastrointest Endosc. 2001;53(4):443-8.
Lahner, E., Caruana, P., D'Ambra, G., Ferraro, G., Di Giulio, E., Delle Fave, G., Bordi, C., & Annibale, B. (2001). First endoscopic-histologic follow-up in patients with body-predominant atrophic gastritis: when should it be done? Gastrointestinal Endoscopy, 53(4), 443-8.
Lahner E, et al. First Endoscopic-histologic Follow-up in Patients With Body-predominant Atrophic Gastritis: when Should It Be Done. Gastrointest Endosc. 2001;53(4):443-8. PubMed PMID: 11275884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - First endoscopic-histologic follow-up in patients with body-predominant atrophic gastritis: when should it be done? AU - Lahner,E, AU - Caruana,P, AU - D'Ambra,G, AU - Ferraro,G, AU - Di Giulio,E, AU - Delle Fave,G, AU - Bordi,C, AU - Annibale,B, PY - 2001/3/29/pubmed PY - 2001/8/10/medline PY - 2001/3/29/entrez SP - 443 EP - 8 JF - Gastrointestinal endoscopy JO - Gastrointest. Endosc. VL - 53 IS - 4 N2 - BACKGROUND: Body-predominant atrophic gastritis is considered a risk factor for gastric cancer and carcinoid. Timing of follow-up for patients with this disorder has not been defined. This study was undertaken to determine the optimal time for the first endoscopic/histologic follow-up in patients with body-predominant atrophic gastritis. METHODS: Forty-two patients with body-predominant atrophic gastritis were randomly assigned to 1 of 2 follow-up intervals: group A (n = 22) at 24 months and group B (n = 20) at 48 months. At baseline and follow-up patients underwent gastroscopy at which biopsies were obtained from the antrum and body for histopathology and evaluation for enterochromaffin-like cells. RESULTS: In group A patients, 2 antral hyperplastic polyps (9.1%) were present at baseline and 4 antral hyperplastic polyps (18.2%) were found at follow-up. In group B patients, baseline gastroscopy revealed 2 antral hyperplastic polyps (10%) and follow-up 2 antral hyperplastic polyps (10%) and 1 carcinoid tumor (5%) in the body. Atrophy and intestinal metaplasia scores in gastric body and antral mucosa in both groups did not change significantly between baseline and follow-up, except an increase in antral mucosa atrophy in group B patients (p = 0.02) was revealed. CONCLUSIONS: The results of this study indicate that performing the first follow-up in patients with body-predominant atrophic gastritis need not be earlier than at 4 years after diagnosis. This interval is satisfactory for detection of potential neoplastic lesions. SN - 0016-5107 UR - https://www.unboundmedicine.com/medline/citation/11275884/First_endoscopic_histologic_follow_up_in_patients_with_body_predominant_atrophic_gastritis:_when_should_it_be_done L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(01)78649-X DB - PRIME DP - Unbound Medicine ER -