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The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review.
Public Health Nutr 2000; 3(4A):509-14PH

Abstract

OBJECTIVE

Feverfew (Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy.

DESIGN

Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted.

RESULTS

Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns.

CONCLUSIONS

Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems.

Authors+Show Affiliations

Department of Complementary Medicine, School of Postgraduate Medicine and Health Science, University of Exeter, UK. e.ernst@exeter.ac.ukNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

11276299

Citation

Ernst, E, and M H. Pittler. "The Efficacy and Safety of Feverfew (Tanacetum Parthenium L.): an Update of a Systematic Review." Public Health Nutrition, vol. 3, no. 4A, 2000, pp. 509-14.
Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr. 2000;3(4A):509-14.
Ernst, E., & Pittler, M. H. (2000). The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutrition, 3(4A), pp. 509-14.
Ernst E, Pittler MH. The Efficacy and Safety of Feverfew (Tanacetum Parthenium L.): an Update of a Systematic Review. Public Health Nutr. 2000;3(4A):509-14. PubMed PMID: 11276299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. AU - Ernst,E, AU - Pittler,M H, PY - 2001/3/29/pubmed PY - 2001/6/2/medline PY - 2001/3/29/entrez SP - 509 EP - 14 JF - Public health nutrition JO - Public Health Nutr VL - 3 IS - 4A N2 - OBJECTIVE: Feverfew (Tanacetum parthenium L.) is a popular herbal remedy often advocated for the prevention of migraine. The aims of this systematic review are to update the evidence from rigorous clinical trials for or against the efficacy of feverfew for migraine prevention and to provide a safety profile of this herbal remedy. DESIGN: Literature searches were performed using the following databases: Medline, Embase, Biosis, CISCOM and the Cochrane Library (all from their inception to December 1999). Only randomized, placebo-controlled, double-blind trials of feverfew mono-preparations for the prevention of migraine in human subjects were included. All articles were read by two independent reviewers. Data were extracted in a pre-defined, standardized fashion. The methodological quality of the trials was evaluated by the Jadad score. For the assessment of safety issues, major reference texts were also consulted. RESULTS: Six trials met the inclusion/exclusion criteria. The majority favour feverfew over placebo. Yet important caveats exist. The data also suggest that feverfew is associated with only mild and transient adverse effects and few other safety concerns. CONCLUSIONS: Feverfew is likely to be effective in the prevention of migraine. There are no major safety problems. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/11276299/The_efficacy_and_safety_of_feverfew__Tanacetum_parthenium_L__:_an_update_of_a_systematic_review_ L2 - https://www.cambridge.org/core/product/identifier/S1368980000000598/type/journal_article DB - PRIME DP - Unbound Medicine ER -