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A major susceptibility locus for leprosy in India maps to chromosome 10p13.
Nat Genet. 2001 Apr; 27(4):439-41.NGen

Abstract

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs.

Authors+Show Affiliations

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11279529

Citation

Siddiqui, M R., et al. "A Major Susceptibility Locus for Leprosy in India Maps to Chromosome 10p13." Nature Genetics, vol. 27, no. 4, 2001, pp. 439-41.
Siddiqui MR, Meisner S, Tosh K, et al. A major susceptibility locus for leprosy in India maps to chromosome 10p13. Nat Genet. 2001;27(4):439-41.
Siddiqui, M. R., Meisner, S., Tosh, K., Balakrishnan, K., Ghei, S., Fisher, S. E., Golding, M., Shanker Narayan, N. P., Sitaraman, T., Sengupta, U., Pitchappan, R., & Hill, A. V. (2001). A major susceptibility locus for leprosy in India maps to chromosome 10p13. Nature Genetics, 27(4), 439-41.
Siddiqui MR, et al. A Major Susceptibility Locus for Leprosy in India Maps to Chromosome 10p13. Nat Genet. 2001;27(4):439-41. PubMed PMID: 11279529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A major susceptibility locus for leprosy in India maps to chromosome 10p13. AU - Siddiqui,M R, AU - Meisner,S, AU - Tosh,K, AU - Balakrishnan,K, AU - Ghei,S, AU - Fisher,S E, AU - Golding,M, AU - Shanker Narayan,N P, AU - Sitaraman,T, AU - Sengupta,U, AU - Pitchappan,R, AU - Hill,A V, PY - 2001/3/30/pubmed PY - 2001/5/1/medline PY - 2001/3/30/entrez SP - 439 EP - 41 JF - Nature genetics JO - Nat. Genet. VL - 27 IS - 4 N2 - Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is prevalent in India, where about half of the world's estimated 800,000 cases occur. A role for the genetics of the host in variable susceptibility to leprosy has been indicated by familial clustering, twin studies, complex segregation analyses and human leukocyte antigen (HLA) association studies. We report here a genetic linkage scan of the genomes of 224 families from South India, containing 245 independent affected sibpairs with leprosy, mainly of the paucibacillary type. In a two-stage genome screen using 396 microsatellite markers, we found significant linkage (maximum lod score (MLS) = 4.09, P < 2x10-5) on chromosome 10p13 for a series of neighboring microsatellite markers, providing evidence for a major locus for this prevalent infectious disease. Thus, despite the polygenic nature of infectious disease susceptibility, some major, non-HLA-linked loci exist that may be mapped through obtainable numbers of affected sibling pairs. SN - 1061-4036 UR - https://www.unboundmedicine.com/medline/citation/11279529/A_major_susceptibility_locus_for_leprosy_in_India_maps_to_chromosome_10p13_ L2 - http://dx.doi.org/10.1038/86958 DB - PRIME DP - Unbound Medicine ER -