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Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients.
J Nephrol 2001 Jan-Feb; 14(1):27-31JN

Abstract

BACKGROUND

Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or homocysteine concentrations in hemodialysis patients.

METHODS

Plasma sulfate, cysteine and homocysteine concentrations and some renal efficiency parameters were determined in 18 patients with end-stage renal failure, all undergoing 4h hemodialysis three times a week. The pattern of post-dialysis rises on plasma concentrations of sulfate, cysteine and homocysteine was established.

RESULTS

Plasma sulfate, cysteine and homocysteine levels were significantly higher in patients than in normal controls. Plasma sulfate concentrations positively correlated with cysteinemia (p = 0.031; r = 0.482) which, in turn correlated with homocysteinemia (p = 0.042; r = 0.460). Sulfate levels also correlated with blood creatinine (p = 0.004; r = 0.630), nitrogen (p = 0.000; r = 0.899), protein (p = 0.014; r = 0.555), and albumin (p = 0.003; r = 0.642). Post-dialysis rises in sulfate and cysteine were detected some hours before homocysteine.

CONCLUSION

The results suggest that high sulfate levels, due mainly to impaired renal function, are involved in the altered metabolism of homocysteine in hemodialysis patients.

Authors+Show Affiliations

Department of Internal Medicine, Perugia University, Italy. bruma@unipg.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11281340

Citation

Brunetti, M, et al. "Plasma Sulfate Concentration and Hyperhomocysteinemia in Hemodialysis Patients." Journal of Nephrology, vol. 14, no. 1, 2001, pp. 27-31.
Brunetti M, Terracina L, Timio M, et al. Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients. J Nephrol. 2001;14(1):27-31.
Brunetti, M., Terracina, L., Timio, M., Saronio, P., & Capodicasa, E. (2001). Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients. Journal of Nephrology, 14(1), pp. 27-31.
Brunetti M, et al. Plasma Sulfate Concentration and Hyperhomocysteinemia in Hemodialysis Patients. J Nephrol. 2001;14(1):27-31. PubMed PMID: 11281340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma sulfate concentration and hyperhomocysteinemia in hemodialysis patients. AU - Brunetti,M, AU - Terracina,L, AU - Timio,M, AU - Saronio,P, AU - Capodicasa,E, PY - 2001/4/3/pubmed PY - 2001/6/15/medline PY - 2001/4/3/entrez SP - 27 EP - 31 JF - Journal of nephrology JO - J. Nephrol. VL - 14 IS - 1 N2 - BACKGROUND: Severe hyperhomocysteinemia is common in hemodialysis patients, who also present a dramatic increase in plasma concentrations of sulfate, one of the main products of methionine and cysteine catabolism. The aim of this study was to verify the relationship between high plasma sulfate levels and cysteine or homocysteine concentrations in hemodialysis patients. METHODS: Plasma sulfate, cysteine and homocysteine concentrations and some renal efficiency parameters were determined in 18 patients with end-stage renal failure, all undergoing 4h hemodialysis three times a week. The pattern of post-dialysis rises on plasma concentrations of sulfate, cysteine and homocysteine was established. RESULTS: Plasma sulfate, cysteine and homocysteine levels were significantly higher in patients than in normal controls. Plasma sulfate concentrations positively correlated with cysteinemia (p = 0.031; r = 0.482) which, in turn correlated with homocysteinemia (p = 0.042; r = 0.460). Sulfate levels also correlated with blood creatinine (p = 0.004; r = 0.630), nitrogen (p = 0.000; r = 0.899), protein (p = 0.014; r = 0.555), and albumin (p = 0.003; r = 0.642). Post-dialysis rises in sulfate and cysteine were detected some hours before homocysteine. CONCLUSION: The results suggest that high sulfate levels, due mainly to impaired renal function, are involved in the altered metabolism of homocysteine in hemodialysis patients. SN - 1121-8428 UR - https://www.unboundmedicine.com/medline/citation/11281340/Plasma_sulfate_concentration_and_hyperhomocysteinemia_in_hemodialysis_patients_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -