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Carbamazepine prevents imipramine-induced behavioural sensitization to the dopamine D(2)-like receptor agonist quinpirole.
Eur J Pharmacol. 2001 Mar 23; 416(1-2):107-11.EJ

Abstract

Chronic treatment with antidepressants potentiates the behavioural sensitivity to the administration of dopamine receptor agonists. Such supersensitivity might be involved in the mechanism of action of antidepressant drugs, but it has also been suggested to play a role in the mechanisms underlying antidepressant treatment-related mania (i.e. antidepressant-induced mood switch and rapid cycling). Consistently to this hypothesis, we have recently shown that lithium salts, which are poorly effective in antidepressant-related mania, fail to prevent the development of imipramine-induced supersensitivity to the locomotor effect of the dopamine D(2)-like receptor agonist quinpirole. In the present paper, we report the ability of carbamazepine, an anticonvulsant with antimanic and mood stabiliser properties, to prevent the development of supersensitivity to the locomotor response to quinpirole induced by chronic treatment with imipramine. The present results, together with the results of our previous study, might contribute to explain the different responsiveness to lithium and carbamazepine observed in some manic patients, and are consistent with the clinical data suggesting that carbamazepine might be more effective than lithium in antidepressant-related mania.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, via Muroni 23/a, 07100, Sassari, Italy. dsfpaolo@ssmain.uniss.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11282119

Citation

D'Aquila, P S., et al. "Carbamazepine Prevents Imipramine-induced Behavioural Sensitization to the Dopamine D(2)-like Receptor Agonist Quinpirole." European Journal of Pharmacology, vol. 416, no. 1-2, 2001, pp. 107-11.
D'Aquila PS, Peana AT, Tanda O, et al. Carbamazepine prevents imipramine-induced behavioural sensitization to the dopamine D(2)-like receptor agonist quinpirole. Eur J Pharmacol. 2001;416(1-2):107-11.
D'Aquila, P. S., Peana, A. T., Tanda, O., & Serra, G. (2001). Carbamazepine prevents imipramine-induced behavioural sensitization to the dopamine D(2)-like receptor agonist quinpirole. European Journal of Pharmacology, 416(1-2), 107-11.
D'Aquila PS, et al. Carbamazepine Prevents Imipramine-induced Behavioural Sensitization to the Dopamine D(2)-like Receptor Agonist Quinpirole. Eur J Pharmacol. 2001 Mar 23;416(1-2):107-11. PubMed PMID: 11282119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbamazepine prevents imipramine-induced behavioural sensitization to the dopamine D(2)-like receptor agonist quinpirole. AU - D'Aquila,P S, AU - Peana,A T, AU - Tanda,O, AU - Serra,G, PY - 2001/4/3/pubmed PY - 2001/7/31/medline PY - 2001/4/3/entrez SP - 107 EP - 11 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 416 IS - 1-2 N2 - Chronic treatment with antidepressants potentiates the behavioural sensitivity to the administration of dopamine receptor agonists. Such supersensitivity might be involved in the mechanism of action of antidepressant drugs, but it has also been suggested to play a role in the mechanisms underlying antidepressant treatment-related mania (i.e. antidepressant-induced mood switch and rapid cycling). Consistently to this hypothesis, we have recently shown that lithium salts, which are poorly effective in antidepressant-related mania, fail to prevent the development of imipramine-induced supersensitivity to the locomotor effect of the dopamine D(2)-like receptor agonist quinpirole. In the present paper, we report the ability of carbamazepine, an anticonvulsant with antimanic and mood stabiliser properties, to prevent the development of supersensitivity to the locomotor response to quinpirole induced by chronic treatment with imipramine. The present results, together with the results of our previous study, might contribute to explain the different responsiveness to lithium and carbamazepine observed in some manic patients, and are consistent with the clinical data suggesting that carbamazepine might be more effective than lithium in antidepressant-related mania. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/11282119/Carbamazepine_prevents_imipramine_induced_behavioural_sensitization_to_the_dopamine_D_2__like_receptor_agonist_quinpirole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(01)00876-7 DB - PRIME DP - Unbound Medicine ER -