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A comprehensive neurobehavioral and neurophysiological study for low level lead-exposed workers.
G Ital Med Lav Ergon. 2000 Oct-Dec; 22(4):299-304.GI

Abstract

A comprehensive neurobehavioral and neurophysiological study was performed to evaluate the adverse effect of low level lead-exposure, and to compare the sensibility, easiness of the test methods utilized. The tests were: WHO recommended Neurobehavioral Core Test Battery (NCTB), Autonomic Nouvers System Function (ANS) Test Battery, Brain Electricity Active Mapping (BEAM), and Nerve Conduction Velocity. 44 lead-exposed workers were selected, with 34 age, education degree, family economic level, smoking and drinking matched referents.

RESULT

The mean blood lead concentration of lead-exposed workers was 1.3870 mumol/L, whereas that of referents was 0.6080 mumol/L, the difference was very significant. The negative Profile of Mood State (POMS) score of lead-expose workers was higher than that of referents, whereas the positive POMS score of the referents was higher than that of lead-exposed group, with a covariance analysis. The lead-exposure affected some NCTB test items, such as simple reaction time (SRT), digital symbol (DSY), correct dots (PAC) and total dots (PA). The heart-rate response to Valsalva manoeuvre (HR-V), heart-rate response to deep breathing (HR-DB), and blood-pressure response to immediate standing (BP-IS) were lowered in lead-exposed workers significantly. Some abnormal brain electric waves (dominant beta frequency, semetry-diffuse abnormal and non semetry-diffuse abnormal wave distribution, dominant low wave amplitude) appeared in lead-exposed workers. Left ulnar nerve maximal conduction velocity was significantly lowered in lead-exposed group.

CONCLUSION

The NCTB (including POMS), and ANS function test should be the regular screening battery for low level lead-exposed workers. The threshold blood lead concentration for health surveillance should be 30 micrograms/dL, or 1.4 mumol/L.

Authors+Show Affiliations

Department of Occupational Health, Shanxi Medical University, Taiyuan 030001, P.R. China. SXYDWSXY@public.ty.sx.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11284152

Citation

Niu, Q, et al. "A Comprehensive Neurobehavioral and Neurophysiological Study for Low Level Lead-exposed Workers." Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, vol. 22, no. 4, 2000, pp. 299-304.
Niu Q, He SC, Li HY, et al. A comprehensive neurobehavioral and neurophysiological study for low level lead-exposed workers. G Ital Med Lav Ergon. 2000;22(4):299-304.
Niu, Q., He, S. C., Li, H. Y., Wang, J. Y., Dai, F. Y., & Chen, Y. L. (2000). A comprehensive neurobehavioral and neurophysiological study for low level lead-exposed workers. Giornale Italiano Di Medicina Del Lavoro Ed Ergonomia, 22(4), 299-304.
Niu Q, et al. A Comprehensive Neurobehavioral and Neurophysiological Study for Low Level Lead-exposed Workers. G Ital Med Lav Ergon. 2000 Oct-Dec;22(4):299-304. PubMed PMID: 11284152.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comprehensive neurobehavioral and neurophysiological study for low level lead-exposed workers. AU - Niu,Q, AU - He,S C, AU - Li,H Y, AU - Wang,J Y, AU - Dai,F Y, AU - Chen,Y L, PY - 2001/4/4/pubmed PY - 2001/7/4/medline PY - 2001/4/4/entrez SP - 299 EP - 304 JF - Giornale italiano di medicina del lavoro ed ergonomia JO - G Ital Med Lav Ergon VL - 22 IS - 4 N2 - UNLABELLED: A comprehensive neurobehavioral and neurophysiological study was performed to evaluate the adverse effect of low level lead-exposure, and to compare the sensibility, easiness of the test methods utilized. The tests were: WHO recommended Neurobehavioral Core Test Battery (NCTB), Autonomic Nouvers System Function (ANS) Test Battery, Brain Electricity Active Mapping (BEAM), and Nerve Conduction Velocity. 44 lead-exposed workers were selected, with 34 age, education degree, family economic level, smoking and drinking matched referents. RESULT: The mean blood lead concentration of lead-exposed workers was 1.3870 mumol/L, whereas that of referents was 0.6080 mumol/L, the difference was very significant. The negative Profile of Mood State (POMS) score of lead-expose workers was higher than that of referents, whereas the positive POMS score of the referents was higher than that of lead-exposed group, with a covariance analysis. The lead-exposure affected some NCTB test items, such as simple reaction time (SRT), digital symbol (DSY), correct dots (PAC) and total dots (PA). The heart-rate response to Valsalva manoeuvre (HR-V), heart-rate response to deep breathing (HR-DB), and blood-pressure response to immediate standing (BP-IS) were lowered in lead-exposed workers significantly. Some abnormal brain electric waves (dominant beta frequency, semetry-diffuse abnormal and non semetry-diffuse abnormal wave distribution, dominant low wave amplitude) appeared in lead-exposed workers. Left ulnar nerve maximal conduction velocity was significantly lowered in lead-exposed group. CONCLUSION: The NCTB (including POMS), and ANS function test should be the regular screening battery for low level lead-exposed workers. The threshold blood lead concentration for health surveillance should be 30 micrograms/dL, or 1.4 mumol/L. SN - 1592-7830 UR - https://www.unboundmedicine.com/medline/citation/11284152/A_comprehensive_neurobehavioral_and_neurophysiological_study_for_low_level_lead_exposed_workers_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -