Tags

Type your tag names separated by a space and hit enter

[Polymorphisms in genes for cholesterol ester transfer protein, apolipoprotein C-III and lipoprotein lipase in children with high and low cholesterol levels] ].
Cas Lek Cesk. 2001 Feb 15; 140(3):79-81.CL

Abstract

BACKGROUND

High plasma lipids are one of the risk factor of atherosclerosis. The contribution of environmental and genetic factors to plasma lipids is roughly equal. Cholesterol ester transfer protein (CETP), lipoprotein lipase (LPL) and apolipoprotein (apo) CIII play an important role in plasma lipid metabolism. The aim of the study was to establish the role of polymorphisms in these genes in plasma lipid determination.

METHODS AND RESULTS

Using PCR and restriction analysis we have measured Taq1 polymorphism in CETP, asparagine 291/serine polymorphism in LPL and C3238G polymorphism in apo CIII genes in two groups of children selected from opposite ends of the cholesterol distribution curve of 2000 children. 82 children in high- (HCG) and 86 in low- (LCG) cholesterol group participated in the study. No significant difference was found in the frequencies of the CETP and apo CIII genotypes between LCG and HCG. In the LCG, significantly more carriers (p < 0.05) of the LPL serine291 allele were found.

CONCLUSIONS

Common polymorphisms in the CETP and apo CIII genes do not determine the plasma lipid levels in childhood. The carriers of the rare allele in the LPL gene could be genetically predisposed to low plasma lipid levels.

Authors+Show Affiliations

Institut klinické a experimentální medicíny, Praha. jaroslav.hubacek@medicon.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

cze

PubMed ID

11284423

Citation

Hubácek, J A., et al. "[Polymorphisms in Genes for Cholesterol Ester Transfer Protein, Apolipoprotein C-III and Lipoprotein Lipase in Children With High and Low Cholesterol Levels] ]." Casopis Lekaru Ceskych, vol. 140, no. 3, 2001, pp. 79-81.
Hubácek JA, Pistulková H, Skodová Z, et al. [Polymorphisms in genes for cholesterol ester transfer protein, apolipoprotein C-III and lipoprotein lipase in children with high and low cholesterol levels] ]. Cas Lek Cesk. 2001;140(3):79-81.
Hubácek, J. A., Pistulková, H., Skodová, Z., Lánská, V., & Poledne, R. (2001). [Polymorphisms in genes for cholesterol ester transfer protein, apolipoprotein C-III and lipoprotein lipase in children with high and low cholesterol levels] ]. Casopis Lekaru Ceskych, 140(3), 79-81.
Hubácek JA, et al. [Polymorphisms in Genes for Cholesterol Ester Transfer Protein, Apolipoprotein C-III and Lipoprotein Lipase in Children With High and Low Cholesterol Levels] ]. Cas Lek Cesk. 2001 Feb 15;140(3):79-81. PubMed PMID: 11284423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Polymorphisms in genes for cholesterol ester transfer protein, apolipoprotein C-III and lipoprotein lipase in children with high and low cholesterol levels] ]. AU - Hubácek,J A, AU - Pistulková,H, AU - Skodová,Z, AU - Lánská,V, AU - Poledne,R, PY - 2001/4/4/pubmed PY - 2001/5/22/medline PY - 2001/4/4/entrez SP - 79 EP - 81 JF - Casopis lekaru ceskych JO - Cas Lek Cesk VL - 140 IS - 3 N2 - BACKGROUND: High plasma lipids are one of the risk factor of atherosclerosis. The contribution of environmental and genetic factors to plasma lipids is roughly equal. Cholesterol ester transfer protein (CETP), lipoprotein lipase (LPL) and apolipoprotein (apo) CIII play an important role in plasma lipid metabolism. The aim of the study was to establish the role of polymorphisms in these genes in plasma lipid determination. METHODS AND RESULTS: Using PCR and restriction analysis we have measured Taq1 polymorphism in CETP, asparagine 291/serine polymorphism in LPL and C3238G polymorphism in apo CIII genes in two groups of children selected from opposite ends of the cholesterol distribution curve of 2000 children. 82 children in high- (HCG) and 86 in low- (LCG) cholesterol group participated in the study. No significant difference was found in the frequencies of the CETP and apo CIII genotypes between LCG and HCG. In the LCG, significantly more carriers (p < 0.05) of the LPL serine291 allele were found. CONCLUSIONS: Common polymorphisms in the CETP and apo CIII genes do not determine the plasma lipid levels in childhood. The carriers of the rare allele in the LPL gene could be genetically predisposed to low plasma lipid levels. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/11284423/[Polymorphisms_in_genes_for_cholesterol_ester_transfer_protein_apolipoprotein_C_III_and_lipoprotein_lipase_in_children_with_high_and_low_cholesterol_levels]_]_ L2 - https://medlineplus.gov/cholesterollevelswhatyouneedtoknow.html DB - PRIME DP - Unbound Medicine ER -