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A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry.
J Sleep Res 2001; 10(1):53-8JS

Abstract

Responses to the eight-item Epworth Sleepiness Scale (ESS) obtained from 1560 World War II male veteran twin pairs [818 monozygotic (MZ), 742 dizygotic (DZ)] were analysed to determine the extent to which genetic influences are involved in self-reported daytime sleepiness in the elderly. Average ESS score (+/- SD) in this sample was 7.1 +/- 3.9, range 0--24. More than half of the twins (65%--67%) reported a moderate to high chance of falling asleep while lying down to rest; fewer than 3% admitted that this would occur while sitting and talking to someone or while stopped in traffic. Daytime sleepiness was not associated with age but was significantly and positively associated with obesity. The intraclass twin correlation on ESS scores was 0.39 in MZ pairs and 0.21 in DZ pairs (both P < 0.001). Structural equation modeling of the observed variance-covariance matrices for MZ and DZ twins estimated the heritability of ESS to be 38% (95% confidence interval 33%--44%). Environmental influences not shared by twin brothers accounted for the remaining variance in daytime sleepiness. A reasonable interpretation of the heritability of ESS in this healthy cohort of elderly male twins is a genetic susceptibility for disordered breathing during sleep.

Authors+Show Affiliations

SRI International, Menlo Park, CA, USA; Emory University Medical Center, Atlanta, GA, USA; Indiana University, Indianapolis, IN, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Twin Study

Language

eng

PubMed ID

11285055

Citation

Carmelli, D, et al. "A Genetic Analysis of the Epworth Sleepiness Scale in 1560 World War II Male Veteran Twins in the NAS-NRC Twin Registry." Journal of Sleep Research, vol. 10, no. 1, 2001, pp. 53-8.
Carmelli D, Bliwise DL, Swan GE, et al. A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry. J Sleep Res. 2001;10(1):53-8.
Carmelli, D., Bliwise, D. L., Swan, G. E., & Reed, T. (2001). A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry. Journal of Sleep Research, 10(1), pp. 53-8.
Carmelli D, et al. A Genetic Analysis of the Epworth Sleepiness Scale in 1560 World War II Male Veteran Twins in the NAS-NRC Twin Registry. J Sleep Res. 2001;10(1):53-8. PubMed PMID: 11285055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A genetic analysis of the Epworth Sleepiness Scale in 1560 World War II male veteran twins in the NAS-NRC Twin Registry. AU - Carmelli,D, AU - Bliwise,D L, AU - Swan,G E, AU - Reed,T, PY - 2001/4/4/pubmed PY - 2001/6/6/medline PY - 2001/4/4/entrez SP - 53 EP - 8 JF - Journal of sleep research JO - J Sleep Res VL - 10 IS - 1 N2 - Responses to the eight-item Epworth Sleepiness Scale (ESS) obtained from 1560 World War II male veteran twin pairs [818 monozygotic (MZ), 742 dizygotic (DZ)] were analysed to determine the extent to which genetic influences are involved in self-reported daytime sleepiness in the elderly. Average ESS score (+/- SD) in this sample was 7.1 +/- 3.9, range 0--24. More than half of the twins (65%--67%) reported a moderate to high chance of falling asleep while lying down to rest; fewer than 3% admitted that this would occur while sitting and talking to someone or while stopped in traffic. Daytime sleepiness was not associated with age but was significantly and positively associated with obesity. The intraclass twin correlation on ESS scores was 0.39 in MZ pairs and 0.21 in DZ pairs (both P < 0.001). Structural equation modeling of the observed variance-covariance matrices for MZ and DZ twins estimated the heritability of ESS to be 38% (95% confidence interval 33%--44%). Environmental influences not shared by twin brothers accounted for the remaining variance in daytime sleepiness. A reasonable interpretation of the heritability of ESS in this healthy cohort of elderly male twins is a genetic susceptibility for disordered breathing during sleep. SN - 0962-1105 UR - https://www.unboundmedicine.com/medline/citation/11285055/A_genetic_analysis_of_the_Epworth_Sleepiness_Scale_in_1560_World_War_II_male_veteran_twins_in_the_NAS_NRC_Twin_Registry_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0962-1105&amp;date=2001&amp;volume=10&amp;issue=1&amp;spage=53 DB - PRIME DP - Unbound Medicine ER -