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Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population.
Psychiatry Clin Neurosci. 2001 Apr; 55(2):115-20.PC

Abstract

The gene for human apolipoprotein E (APOE) is found on the long arm of chromosome 19 (19q13.2) and exists in three common allelic forms, epsilon2, epsilon3, and epsilon4. The APOE epsilon4 allele is overrepresented in Alzheimer's disease (AD) and is accepted as a genetic risk factor. Some studies reported a protective effect of the APOE epsilon2 allele for AD. However, there are some ethnic variations in the proportion of different APOE alleles and their relationship to AD. We examine the distribution of APOE alleles from 30 AD patients and 158 controls in Korea. The control subjects were all cognitively intact unrelated Koreans. The frequencies of APOE alleles in AD patients were 18.3% (epsilon2), 58.3% (epsilon3), and 23.3% (epsilon4). The corresponding frequencies in controls were 13.3% (epsilon2), 72.5% (epsilon3), and 14.2% (epsilon4). The frequency of the APOE epsilon2 allele in AD patients was not significantly different from that in controls. When statistical analysis was conducted after the exclusion of the APOE epsilon2 allele, the frequency of the APOE epsilon4 allele in AD patients was significantly higher than that in controls (P < 0.05). These results support that the APOE epsilon4 allele plays a role as a risk factor for AD in Koreans and suggest that the APOE epsilon2 allele may not play a protective role in the development of AD in Koreans.

Authors+Show Affiliations

Kim HC
Department of Psychiatry, Institute for Medical Genetics, Keimyung University School of Medicine, Korea. mdhck@dsmc.or.kr
Kim DK
No affiliation info available
Choi IJ
No affiliation info available
Kang KH
No affiliation info available
Yi SD
No affiliation info available
Park J
No affiliation info available
Park YN
No affiliation info available

MeSH

AdultAgedAlzheimer DiseaseApolipoproteins EFemaleGene FrequencyGenotypeHumansKoreaMaleMiddle AgedPolymerase Chain Reaction

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11285089

Citation

Kim, H C., et al. "Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Alzheimer's Disease in the Korean Population." Psychiatry and Clinical Neurosciences, vol. 55, no. 2, 2001, pp. 115-20.
Kim HC, Kim DK, Choi IJ, et al. Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population. Psychiatry Clin Neurosci. 2001;55(2):115-20.
Kim, H. C., Kim, D. K., Choi, I. J., Kang, K. H., Yi, S. D., Park, J., & Park, Y. N. (2001). Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population. Psychiatry and Clinical Neurosciences, 55(2), 115-20.
Kim HC, et al. Relation of Apolipoprotein E Polymorphism to Clinically Diagnosed Alzheimer's Disease in the Korean Population. Psychiatry Clin Neurosci. 2001;55(2):115-20. PubMed PMID: 11285089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation of apolipoprotein E polymorphism to clinically diagnosed Alzheimer's disease in the Korean population. AU - Kim,H C, AU - Kim,D K, AU - Choi,I J, AU - Kang,K H, AU - Yi,S D, AU - Park,J, AU - Park,Y N, PY - 2001/4/4/pubmed PY - 2001/8/29/medline PY - 2001/4/4/entrez SP - 115 EP - 20 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin Neurosci VL - 55 IS - 2 N2 - The gene for human apolipoprotein E (APOE) is found on the long arm of chromosome 19 (19q13.2) and exists in three common allelic forms, epsilon2, epsilon3, and epsilon4. The APOE epsilon4 allele is overrepresented in Alzheimer's disease (AD) and is accepted as a genetic risk factor. Some studies reported a protective effect of the APOE epsilon2 allele for AD. However, there are some ethnic variations in the proportion of different APOE alleles and their relationship to AD. We examine the distribution of APOE alleles from 30 AD patients and 158 controls in Korea. The control subjects were all cognitively intact unrelated Koreans. The frequencies of APOE alleles in AD patients were 18.3% (epsilon2), 58.3% (epsilon3), and 23.3% (epsilon4). The corresponding frequencies in controls were 13.3% (epsilon2), 72.5% (epsilon3), and 14.2% (epsilon4). The frequency of the APOE epsilon2 allele in AD patients was not significantly different from that in controls. When statistical analysis was conducted after the exclusion of the APOE epsilon2 allele, the frequency of the APOE epsilon4 allele in AD patients was significantly higher than that in controls (P < 0.05). These results support that the APOE epsilon4 allele plays a role as a risk factor for AD in Koreans and suggest that the APOE epsilon2 allele may not play a protective role in the development of AD in Koreans. SN - 1323-1316 UR - https://www.unboundmedicine.com/medline/citation/11285089/Relation_of_apolipoprotein_E_polymorphism_to_clinically_diagnosed_Alzheimer's_disease_in_the_Korean_population_ DB - PRIME DP - Unbound Medicine ER -