The molecular basis of copper-transport diseases.Trends Mol Med. 2001 Feb; 7(2):64-9.TM
Abstract
Copper (Cu) is a potentially toxic yet essential element. MENKES DISEASE, a copper deficiency disorder, and WILSON DISEASE, a copper toxicosis condition, are two human genetic disorders, caused by mutations of two closely related Cu-transporting ATPases. Both molecules efflux copper from cells. Quite diverse clinical phenotypes are produced by different mutations of these two Cu-transporting proteins. The understanding of copper homeostasis has become increasingly important in clinical medicine as the metal could be involved in the pathogenesis of some important neurological disorders such as Alzheimer's disease, motor neurone diseases and prion diseases.
Links
MeSH
Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
11286757
Citation
Mercer, J F.. "The Molecular Basis of Copper-transport Diseases." Trends in Molecular Medicine, vol. 7, no. 2, 2001, pp. 64-9.
Mercer JF. The molecular basis of copper-transport diseases. Trends Mol Med. 2001;7(2):64-9.
Mercer, J. F. (2001). The molecular basis of copper-transport diseases. Trends in Molecular Medicine, 7(2), 64-9.
Mercer JF. The Molecular Basis of Copper-transport Diseases. Trends Mol Med. 2001;7(2):64-9. PubMed PMID: 11286757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - The molecular basis of copper-transport diseases.
A1 - Mercer,J F,
PY - 2001/4/5/pubmed
PY - 2001/6/2/medline
PY - 2001/4/5/entrez
SP - 64
EP - 9
JF - Trends in molecular medicine
JO - Trends Mol Med
VL - 7
IS - 2
N2 - Copper (Cu) is a potentially toxic yet essential element. MENKES DISEASE, a copper deficiency disorder, and WILSON DISEASE, a copper toxicosis condition, are two human genetic disorders, caused by mutations of two closely related Cu-transporting ATPases. Both molecules efflux copper from cells. Quite diverse clinical phenotypes are produced by different mutations of these two Cu-transporting proteins. The understanding of copper homeostasis has become increasingly important in clinical medicine as the metal could be involved in the pathogenesis of some important neurological disorders such as Alzheimer's disease, motor neurone diseases and prion diseases.
SN - 1471-4914
UR - https://www.unboundmedicine.com/medline/citation/11286757/The_molecular_basis_of_copper_transport_diseases_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4914(01)01920-7
DB - PRIME
DP - Unbound Medicine
ER -