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Chlamydia pneumoniae and multiple sclerosis: no significant association.
Trends Microbiol 2001; 9(4):152-4TM

Abstract

The cause of multiple sclerosis (MS) is unknown. Despite indications from epidemiological and identical-twin studies that MS is infectious, no virus or other infectious agent has been tightly linked to disease. The isolation of Chlamydia pneumoniae from the cerebrospinal fluid (CSF) of MS patients and the detection of both Chlamydia-specific DNA and antibody in MS CSF have been reported. Other analyses of brain and CSF have shown no significant difference in C. pneumoniae-specific DNA or antibody between MS and control subjects. Recent work has revealed intrathecal production of C. pneumoniae-specific IgG in only 24% of MS patients compared with 5% of control patients. More importantly, the major CSF oligoclonal bands from MS patients did not react to C. pneumoniae.

Authors+Show Affiliations

Dept of Microbiology and the Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11286864

Citation

Tsai, J C., and D H. Gilden. "Chlamydia Pneumoniae and Multiple Sclerosis: No Significant Association." Trends in Microbiology, vol. 9, no. 4, 2001, pp. 152-4.
Tsai JC, Gilden DH. Chlamydia pneumoniae and multiple sclerosis: no significant association. Trends Microbiol. 2001;9(4):152-4.
Tsai, J. C., & Gilden, D. H. (2001). Chlamydia pneumoniae and multiple sclerosis: no significant association. Trends in Microbiology, 9(4), pp. 152-4.
Tsai JC, Gilden DH. Chlamydia Pneumoniae and Multiple Sclerosis: No Significant Association. Trends Microbiol. 2001;9(4):152-4. PubMed PMID: 11286864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlamydia pneumoniae and multiple sclerosis: no significant association. AU - Tsai,J C, AU - Gilden,D H, PY - 2001/4/5/pubmed PY - 2001/8/17/medline PY - 2001/4/5/entrez SP - 152 EP - 4 JF - Trends in microbiology JO - Trends Microbiol. VL - 9 IS - 4 N2 - The cause of multiple sclerosis (MS) is unknown. Despite indications from epidemiological and identical-twin studies that MS is infectious, no virus or other infectious agent has been tightly linked to disease. The isolation of Chlamydia pneumoniae from the cerebrospinal fluid (CSF) of MS patients and the detection of both Chlamydia-specific DNA and antibody in MS CSF have been reported. Other analyses of brain and CSF have shown no significant difference in C. pneumoniae-specific DNA or antibody between MS and control subjects. Recent work has revealed intrathecal production of C. pneumoniae-specific IgG in only 24% of MS patients compared with 5% of control patients. More importantly, the major CSF oligoclonal bands from MS patients did not react to C. pneumoniae. SN - 0966-842X UR - https://www.unboundmedicine.com/medline/citation/11286864/Chlamydia_pneumoniae_and_multiple_sclerosis:_no_significant_association_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0966-842X(01)01985-0 DB - PRIME DP - Unbound Medicine ER -