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Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease.
Brain. 2001 Apr; 124(Pt 4):784-92.B

Abstract

The basal ganglia play a role in controlling movement during gait. The aim of the present study was to investigate changes in dopamine transporter (DAT) availability in the striatum and extrastriatal region in association with walking exercise in six normal subjects and seven age-matched unmedicated patients with Parkinson's disease. This was done by comparing DAT radioligand uptake in the dopaminergic projection areas after gait with that under the resting condition using a DAT probe, 11C-labelled 2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane ([11C]CFT) and PET. Physiological parameters were stable during and after gait in both groups. The regions of interest method for measuring differences in [11C]CFT uptake level and voxel-based statistical parametric mapping (SPM96) showed that [11C]CFT uptake in the striatum (specifically the putamen) was decreased by gait to a greater extent in normal subjects, whereas a significant reduction in [11C]CFT uptake was not found in the putamen but in the caudate and orbitofrontal cortex in Parkinson's disease patients. These results are the first in vivo evidence that DAT availability is reduced in the nigrostriatal projection area by basic human behaviour, i.e. gait. Alterations in this availability in Parkinson's disease suggested that shifted activation in the medial striatum and the mesocortical dopaminergic system might reflect the pathophysiology of parkinsonian gait.

Authors+Show Affiliations

Positron Medical Center, Hamakita Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

11287377

Citation

Ouchi, Y, et al. "Changes in Dopamine Availability in the Nigrostriatal and Mesocortical Dopaminergic Systems By Gait in Parkinson's Disease." Brain : a Journal of Neurology, vol. 124, no. Pt 4, 2001, pp. 784-92.
Ouchi Y, Kanno T, Okada H, et al. Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain. 2001;124(Pt 4):784-92.
Ouchi, Y., Kanno, T., Okada, H., Yoshikawa, E., Futatsubashi, M., Nobezawa, S., Torizuka, T., & Tanaka, K. (2001). Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. Brain : a Journal of Neurology, 124(Pt 4), 784-92.
Ouchi Y, et al. Changes in Dopamine Availability in the Nigrostriatal and Mesocortical Dopaminergic Systems By Gait in Parkinson's Disease. Brain. 2001;124(Pt 4):784-92. PubMed PMID: 11287377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in dopamine availability in the nigrostriatal and mesocortical dopaminergic systems by gait in Parkinson's disease. AU - Ouchi,Y, AU - Kanno,T, AU - Okada,H, AU - Yoshikawa,E, AU - Futatsubashi,M, AU - Nobezawa,S, AU - Torizuka,T, AU - Tanaka,K, PY - 2001/4/5/pubmed PY - 2001/5/22/medline PY - 2001/4/5/entrez SP - 784 EP - 92 JF - Brain : a journal of neurology JO - Brain VL - 124 IS - Pt 4 N2 - The basal ganglia play a role in controlling movement during gait. The aim of the present study was to investigate changes in dopamine transporter (DAT) availability in the striatum and extrastriatal region in association with walking exercise in six normal subjects and seven age-matched unmedicated patients with Parkinson's disease. This was done by comparing DAT radioligand uptake in the dopaminergic projection areas after gait with that under the resting condition using a DAT probe, 11C-labelled 2-beta-carbomethoxy-3beta-(4-fluorophenyl) tropane ([11C]CFT) and PET. Physiological parameters were stable during and after gait in both groups. The regions of interest method for measuring differences in [11C]CFT uptake level and voxel-based statistical parametric mapping (SPM96) showed that [11C]CFT uptake in the striatum (specifically the putamen) was decreased by gait to a greater extent in normal subjects, whereas a significant reduction in [11C]CFT uptake was not found in the putamen but in the caudate and orbitofrontal cortex in Parkinson's disease patients. These results are the first in vivo evidence that DAT availability is reduced in the nigrostriatal projection area by basic human behaviour, i.e. gait. Alterations in this availability in Parkinson's disease suggested that shifted activation in the medial striatum and the mesocortical dopaminergic system might reflect the pathophysiology of parkinsonian gait. SN - 0006-8950 UR - https://www.unboundmedicine.com/medline/citation/11287377/Changes_in_dopamine_availability_in_the_nigrostriatal_and_mesocortical_dopaminergic_systems_by_gait_in_Parkinson's_disease_ L2 - https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/124.4.784 DB - PRIME DP - Unbound Medicine ER -