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Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function.
Metabolism 2001; 50(4):494-503M

Abstract

We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary fiber hypothesis related to colon cancer and heart disease prevention and also may have been eaten early in human evolution. Ten healthy volunteers each took 3 metabolic diets of 2 weeks duration. The diets were: high-vegetable, fruit, and nut (very-high-fiber, 55 g/1,000 kcal); starch-based containing cereals and legumes (early agricultural diet); or low-fat (contemporary therapeutic diet). All diets were intended to be weight-maintaining (mean intake, 2,577 kcal/d). Compared with the starch-based and low-fat diets, the high-fiber vegetable diet resulted in the largest reduction in low-density lipoprotein (LDL) cholesterol (33% +/- 4%, P <.001) and the greatest fecal bile acid output (1.13 +/- 0.30 g/d, P =.002), fecal bulk (906 +/- 130 g/d, P <.001), and fecal short-chain fatty acid outputs (78 +/- 13 mmol/d, P <.001). Nevertheless, due to the increase in fecal bulk, the actual concentrations of fecal bile acids were lowest on the vegetable diet (1.2 mg/g wet weight, P =.002). Maximum lipid reductions occurred within 1 week. Urinary mevalonic acid excretion increased (P =.036) on the high-vegetable diet reflecting large fecal steroid losses. We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation.

Authors+Show Affiliations

Clinical Nutrition and Risk Factor Modification Center, Department of Medicine, Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11288049

Citation

Jenkins, D J., et al. "Effect of a Very-high-fiber Vegetable, Fruit, and Nut Diet On Serum Lipids and Colonic Function." Metabolism: Clinical and Experimental, vol. 50, no. 4, 2001, pp. 494-503.
Jenkins DJ, Kendall CW, Popovich DG, et al. Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metab Clin Exp. 2001;50(4):494-503.
Jenkins, D. J., Kendall, C. W., Popovich, D. G., Vidgen, E., Mehling, C. C., Vuksan, V., ... Connelly, P. W. (2001). Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism: Clinical and Experimental, 50(4), pp. 494-503.
Jenkins DJ, et al. Effect of a Very-high-fiber Vegetable, Fruit, and Nut Diet On Serum Lipids and Colonic Function. Metab Clin Exp. 2001;50(4):494-503. PubMed PMID: 11288049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. AU - Jenkins,D J, AU - Kendall,C W, AU - Popovich,D G, AU - Vidgen,E, AU - Mehling,C C, AU - Vuksan,V, AU - Ransom,T P, AU - Rao,A V, AU - Rosenberg-Zand,R, AU - Tariq,N, AU - Corey,P, AU - Jones,P J, AU - Raeini,M, AU - Story,J A, AU - Furumoto,E J, AU - Illingworth,D R, AU - Pappu,A S, AU - Connelly,P W, PY - 2001/4/5/pubmed PY - 2001/5/18/medline PY - 2001/4/5/entrez SP - 494 EP - 503 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 50 IS - 4 N2 - We tested the effects of feeding a diet very high in fiber from fruit and vegetables. The levels fed were those, which had originally inspired the dietary fiber hypothesis related to colon cancer and heart disease prevention and also may have been eaten early in human evolution. Ten healthy volunteers each took 3 metabolic diets of 2 weeks duration. The diets were: high-vegetable, fruit, and nut (very-high-fiber, 55 g/1,000 kcal); starch-based containing cereals and legumes (early agricultural diet); or low-fat (contemporary therapeutic diet). All diets were intended to be weight-maintaining (mean intake, 2,577 kcal/d). Compared with the starch-based and low-fat diets, the high-fiber vegetable diet resulted in the largest reduction in low-density lipoprotein (LDL) cholesterol (33% +/- 4%, P <.001) and the greatest fecal bile acid output (1.13 +/- 0.30 g/d, P =.002), fecal bulk (906 +/- 130 g/d, P <.001), and fecal short-chain fatty acid outputs (78 +/- 13 mmol/d, P <.001). Nevertheless, due to the increase in fecal bulk, the actual concentrations of fecal bile acids were lowest on the vegetable diet (1.2 mg/g wet weight, P =.002). Maximum lipid reductions occurred within 1 week. Urinary mevalonic acid excretion increased (P =.036) on the high-vegetable diet reflecting large fecal steroid losses. We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/11288049/Effect_of_a_very_high_fiber_vegetable_fruit_and_nut_diet_on_serum_lipids_and_colonic_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(01)08204-X DB - PRIME DP - Unbound Medicine ER -