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Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori.
Cancer Res. 2001 Mar 15; 61(6):2684-9.CR

Abstract

DNA and sera from 130 cases of gastric cancer and 263 population-based controls were analyzed to study the association of HLA class II DR-DQ alleles with Helicobacter pylori (Hp) infection and the risk for gastric cancer. Presence of the DQA1*0102 allele was inversely and significantly associated with Hp seropositivity (P = 2 x 10(-5)), which is an independent replication of previous findings. However, this inverse relationship with Hp did not correspond with a reduced risk of gastric cancer. At the DRB1 locus, the *1601 allele was significantly associated with an increased gastric cancer risk with an odds ratio (95% confidence interval) of 8.7 (range, 2.7-28.0). The effect of *1601 was more pronounced among Hp-negative subjects, and the association was stronger with the diffuse, rather than with the intestinal, histological type of gastric cancer. Because none of the HLA alleles were associated with both Hp infection and gastric cancer, the HLA DR-DQ alleles are linked with gastric cancer risk through other mechanisms than an increased susceptibility to Hp infection.

Authors+Show Affiliations

Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, Uppsala, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11289148

Citation

Magnusson PKE, , et al. "Gastric Cancer and Human Leukocyte Antigen: Distinct DQ and DR Alleles Are Associated With Development of Gastric Cancer and Infection By Helicobacter Pylori." Cancer Research, vol. 61, no. 6, 2001, pp. 2684-9.
Magnusson PKE , Enroth H, Eriksson I, et al. Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. Cancer Res. 2001;61(6):2684-9.
Magnusson PKE, ., Enroth, H., Eriksson, I., Held, M., Nyrén, O., Engstrand, L., Hansson, L. E., & Gyllensten, U. B. (2001). Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. Cancer Research, 61(6), 2684-9.
Magnusson PKE , et al. Gastric Cancer and Human Leukocyte Antigen: Distinct DQ and DR Alleles Are Associated With Development of Gastric Cancer and Infection By Helicobacter Pylori. Cancer Res. 2001 Mar 15;61(6):2684-9. PubMed PMID: 11289148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. AU - Magnusson PKE,, AU - Enroth,H, AU - Eriksson,I, AU - Held,M, AU - Nyrén,O, AU - Engstrand,L, AU - Hansson,L E, AU - Gyllensten,U B, PY - 2001/4/6/pubmed PY - 2001/5/1/medline PY - 2001/4/6/entrez SP - 2684 EP - 9 JF - Cancer research JO - Cancer Res VL - 61 IS - 6 N2 - DNA and sera from 130 cases of gastric cancer and 263 population-based controls were analyzed to study the association of HLA class II DR-DQ alleles with Helicobacter pylori (Hp) infection and the risk for gastric cancer. Presence of the DQA1*0102 allele was inversely and significantly associated with Hp seropositivity (P = 2 x 10(-5)), which is an independent replication of previous findings. However, this inverse relationship with Hp did not correspond with a reduced risk of gastric cancer. At the DRB1 locus, the *1601 allele was significantly associated with an increased gastric cancer risk with an odds ratio (95% confidence interval) of 8.7 (range, 2.7-28.0). The effect of *1601 was more pronounced among Hp-negative subjects, and the association was stronger with the diffuse, rather than with the intestinal, histological type of gastric cancer. Because none of the HLA alleles were associated with both Hp infection and gastric cancer, the HLA DR-DQ alleles are linked with gastric cancer risk through other mechanisms than an increased susceptibility to Hp infection. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/11289148/Gastric_cancer_and_human_leukocyte_antigen:_distinct_DQ_and_DR_alleles_are_associated_with_development_of_gastric_cancer_and_infection_by_Helicobacter_pylori_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11289148 DB - PRIME DP - Unbound Medicine ER -