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Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study.
Lancet 2001; 357(9260):922-5Lct

Abstract

BACKGROUND

In some prospective studies, haemorrhagic stroke occurs more frequently in individuals with low serum cholesterol than in those with higher concentrations. We aimed to determine whether low total serum cholesterol is an independent risk factor for haemorrhagic stroke (intracerebral haemorrhage and subarachnoid haemorrhage) in South Korea, a country that has a population with relatively low concentrations of total serum cholesterol.

METHODS

We measured total serum cholesterol and other cardiovascular risk factors in 114,793 Korean men, aged between 35-59 years in 1990 and 1992, in a prospective observational study. We used data obtained in 1992 for smoking and alcohol consumption. We divided total serum cholesterol into quintiles (<4.31 mmol/L, 4.31-<4.74, 4.74-<5.16, 5.16-<5.69 and > or = 5.69). Our primary outcomes were hospital admissions and deaths from intracerebral and subarachnoid haemorrhage in a 6 year follow-up between 1993 and 1998.

FINDINGS

528 men had a haemorrhagic stroke--372 intracerebral and 98 subarachnoid haemorrhage--and 58 were unspecified strokes. The relative risks of intracerebral haemorrhage in each quintile of total serum cholesterol (lowest to highest were: 1.22 (95% CI 0.88-1.69); 0.86 (0.60-1.21); 1.08 (0.78-1.48); and 1.03 (0.75-1.41). The corresponding relative risks for subarachnoid haemorrhage were: 1.44 (0.76-2.73); 1.13 (0.59-2.20); 1.21 (0.64-2.29); and 1.12 (0.59-2.14).

INTERPRETATION

Low total serum cholesterol is not an independent risk factor for either intracerebral or subarachnoid haemorrhagic stroke in Korean men.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, Yonsei University College of Medicine, Seoul, Korea. isuh@yumc.yonsei.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11289349

Citation

Suh, I, et al. "Low Serum Cholesterol and Haemorrhagic Stroke in Men: Korea Medical Insurance Corporation Study." Lancet (London, England), vol. 357, no. 9260, 2001, pp. 922-5.
Suh I, Jee SH, Kim HC, et al. Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. Lancet. 2001;357(9260):922-5.
Suh, I., Jee, S. H., Kim, H. C., Nam, C. M., Kim, I. S., & Appel, L. J. (2001). Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. Lancet (London, England), 357(9260), pp. 922-5.
Suh I, et al. Low Serum Cholesterol and Haemorrhagic Stroke in Men: Korea Medical Insurance Corporation Study. Lancet. 2001 Mar 24;357(9260):922-5. PubMed PMID: 11289349.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. AU - Suh,I, AU - Jee,S H, AU - Kim,H C, AU - Nam,C M, AU - Kim,I S, AU - Appel,L J, PY - 2001/4/6/pubmed PY - 2001/4/21/medline PY - 2001/4/6/entrez SP - 922 EP - 5 JF - Lancet (London, England) JO - Lancet VL - 357 IS - 9260 N2 - BACKGROUND: In some prospective studies, haemorrhagic stroke occurs more frequently in individuals with low serum cholesterol than in those with higher concentrations. We aimed to determine whether low total serum cholesterol is an independent risk factor for haemorrhagic stroke (intracerebral haemorrhage and subarachnoid haemorrhage) in South Korea, a country that has a population with relatively low concentrations of total serum cholesterol. METHODS: We measured total serum cholesterol and other cardiovascular risk factors in 114,793 Korean men, aged between 35-59 years in 1990 and 1992, in a prospective observational study. We used data obtained in 1992 for smoking and alcohol consumption. We divided total serum cholesterol into quintiles (<4.31 mmol/L, 4.31-<4.74, 4.74-<5.16, 5.16-<5.69 and > or = 5.69). Our primary outcomes were hospital admissions and deaths from intracerebral and subarachnoid haemorrhage in a 6 year follow-up between 1993 and 1998. FINDINGS: 528 men had a haemorrhagic stroke--372 intracerebral and 98 subarachnoid haemorrhage--and 58 were unspecified strokes. The relative risks of intracerebral haemorrhage in each quintile of total serum cholesterol (lowest to highest were: 1.22 (95% CI 0.88-1.69); 0.86 (0.60-1.21); 1.08 (0.78-1.48); and 1.03 (0.75-1.41). The corresponding relative risks for subarachnoid haemorrhage were: 1.44 (0.76-2.73); 1.13 (0.59-2.20); 1.21 (0.64-2.29); and 1.12 (0.59-2.14). INTERPRETATION: Low total serum cholesterol is not an independent risk factor for either intracerebral or subarachnoid haemorrhagic stroke in Korean men. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/11289349/Low_serum_cholesterol_and_haemorrhagic_stroke_in_men:_Korea_Medical_Insurance_Corporation_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(00)04213-6 DB - PRIME DP - Unbound Medicine ER -