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Alcohol in breath and blood: a selected ion flow tube mass spectrometric study.
Rapid Commun Mass Spectrom. 2001; 15(6):413-7.RC

Abstract

In this paper we compare the amounts of ethanol in breath and in blood after ingestion of whisky using analysis by selected ion flow tube mass spectrometry (SIFT-MS). Blood ethanol concentrations were also obtained using standard hospital forensic procedures for blood alcohol analyses. We demonstrate the quantitative nature of SIFT-MS analysis by correlating the observed alcohol content of the headspace above 5-mL amounts of venous blood and aqueous solution to which known trace amounts of alcohol have been added. This procedure provides a Henry's Law coefficient for ethanol in aqueous solution at 298 +/- 3 K of 209 +/- 7 mol/kg*bar. We also demonstrate that measurement of the ethanol concentration in the alveolar portion of a single breath using the SIFT-MS technique gives an accurate measure of blood alcohol and could obviate the need for blood samples in forensic processing. The storage performance of breath samples in Mylar bags with a volume greater than 1 L has been shown to maintain the mixture integrity for ethanol but not for some other species.

Authors+Show Affiliations

Department of Chemistry, University of Canterbury, Christchurch, New Zealand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11291119

Citation

Wilson, P F., et al. "Alcohol in Breath and Blood: a Selected Ion Flow Tube Mass Spectrometric Study." Rapid Communications in Mass Spectrometry : RCM, vol. 15, no. 6, 2001, pp. 413-7.
Wilson PF, Freeman CG, McEwan MJ, et al. Alcohol in breath and blood: a selected ion flow tube mass spectrometric study. Rapid Commun Mass Spectrom. 2001;15(6):413-7.
Wilson, P. F., Freeman, C. G., McEwan, M. J., Milligan, D. B., Allardyce, R. A., & Shaw, G. M. (2001). Alcohol in breath and blood: a selected ion flow tube mass spectrometric study. Rapid Communications in Mass Spectrometry : RCM, 15(6), 413-7.
Wilson PF, et al. Alcohol in Breath and Blood: a Selected Ion Flow Tube Mass Spectrometric Study. Rapid Commun Mass Spectrom. 2001;15(6):413-7. PubMed PMID: 11291119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol in breath and blood: a selected ion flow tube mass spectrometric study. AU - Wilson,P F, AU - Freeman,C G, AU - McEwan,M J, AU - Milligan,D B, AU - Allardyce,R A, AU - Shaw,G M, PY - 2001/4/6/pubmed PY - 2001/5/26/medline PY - 2001/4/6/entrez SP - 413 EP - 7 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 15 IS - 6 N2 - In this paper we compare the amounts of ethanol in breath and in blood after ingestion of whisky using analysis by selected ion flow tube mass spectrometry (SIFT-MS). Blood ethanol concentrations were also obtained using standard hospital forensic procedures for blood alcohol analyses. We demonstrate the quantitative nature of SIFT-MS analysis by correlating the observed alcohol content of the headspace above 5-mL amounts of venous blood and aqueous solution to which known trace amounts of alcohol have been added. This procedure provides a Henry's Law coefficient for ethanol in aqueous solution at 298 +/- 3 K of 209 +/- 7 mol/kg*bar. We also demonstrate that measurement of the ethanol concentration in the alveolar portion of a single breath using the SIFT-MS technique gives an accurate measure of blood alcohol and could obviate the need for blood samples in forensic processing. The storage performance of breath samples in Mylar bags with a volume greater than 1 L has been shown to maintain the mixture integrity for ethanol but not for some other species. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/11291119/Alcohol_in_breath_and_blood:_a_selected_ion_flow_tube_mass_spectrometric_study_ L2 - https://doi.org/10.1002/rcm.244 DB - PRIME DP - Unbound Medicine ER -