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Osteopenia in Puerto Ricans with Crohn's disease.
P R Health Sci J. 2000 Dec; 19(4):329-33.PR

Abstract

BACKGROUND

Osteopenia has been reported in association to Inflammatory Bowel Disease, and in particular Crohn's disease. The use of corticosteroids, resection of the ileum, malabsorption, poor calcium intake, and the effect of inflammatory cytokines have all been considered as contributing factors. As Crohn's disease is more prevalent in young people, when peak bone mass is achieved, the presence of osteopenia is especially significant.

OBJECTIVES

The aim of this study was to evaluate the bone density of patients with Crohn's disease in the University of Puerto Rico IBD Clinic; to determine the prevalence of osteopenia in these patients and to correlate bone mineral density with risk factors for osteopenia.

METHODS

Sixty-six patients, 30 males and 36 females were included. After informed consent, demographic, clinical and metabolic data was obtained. Serum albumin, calcium, inorganic phosphorus and alkaline phosphatase were measured. Body mass index (BMI) was calculated. Bone density was determined by DEXA of the lumbar spine and femur and expressed as the Z score (standard deviations from normal correlated with sex and age). Severe osteopenia was a Z score > or = -2 and osteopenia was Z < or = -1.99 or > or = 1.01. Results were expressed in means. Pearson correlation coefficient was used for quantitative variables and Pearson chi-square for categorical values.

RESULTS

Osteopenia was present in the hip in 69% and in the lumbar spine in 68%. Most patients had received steroids; the difference between treated and not treated patients was not significant. Osteopenia did not correlate with ileal resection, gender, BMI, disease characteristics or biochemical parameters.

CONCLUSIONS

Low bone density was frequent in patients with Crohn's disease, but no specific risk factors could be identified. Bone density should be determined in patients with Crohn's disease in order to institute appropriate therapeutic measures.

Authors+Show Affiliations

Gastroenterology Research Unit, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, Puerto Rico, 00936-5067.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11293884

Citation

Chinea, B, et al. "Osteopenia in Puerto Ricans With Crohn's Disease." Puerto Rico Health Sciences Journal, vol. 19, no. 4, 2000, pp. 329-33.
Chinea B, Rosa A, Oharriz JJ, et al. Osteopenia in Puerto Ricans with Crohn's disease. P R Health Sci J. 2000;19(4):329-33.
Chinea, B., Rosa, A., Oharriz, J. J., Ramírez, M., Haddock, L., Pérez, C., & Torres, E. A. (2000). Osteopenia in Puerto Ricans with Crohn's disease. Puerto Rico Health Sciences Journal, 19(4), 329-33.
Chinea B, et al. Osteopenia in Puerto Ricans With Crohn's Disease. P R Health Sci J. 2000;19(4):329-33. PubMed PMID: 11293884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteopenia in Puerto Ricans with Crohn's disease. AU - Chinea,B, AU - Rosa,A, AU - Oharriz,J J, AU - Ramírez,M, AU - Haddock,L, AU - Pérez,C, AU - Torres,E A, PY - 2001/4/11/pubmed PY - 2001/7/6/medline PY - 2001/4/11/entrez SP - 329 EP - 33 JF - Puerto Rico health sciences journal JO - P R Health Sci J VL - 19 IS - 4 N2 - BACKGROUND: Osteopenia has been reported in association to Inflammatory Bowel Disease, and in particular Crohn's disease. The use of corticosteroids, resection of the ileum, malabsorption, poor calcium intake, and the effect of inflammatory cytokines have all been considered as contributing factors. As Crohn's disease is more prevalent in young people, when peak bone mass is achieved, the presence of osteopenia is especially significant. OBJECTIVES: The aim of this study was to evaluate the bone density of patients with Crohn's disease in the University of Puerto Rico IBD Clinic; to determine the prevalence of osteopenia in these patients and to correlate bone mineral density with risk factors for osteopenia. METHODS: Sixty-six patients, 30 males and 36 females were included. After informed consent, demographic, clinical and metabolic data was obtained. Serum albumin, calcium, inorganic phosphorus and alkaline phosphatase were measured. Body mass index (BMI) was calculated. Bone density was determined by DEXA of the lumbar spine and femur and expressed as the Z score (standard deviations from normal correlated with sex and age). Severe osteopenia was a Z score > or = -2 and osteopenia was Z < or = -1.99 or > or = 1.01. Results were expressed in means. Pearson correlation coefficient was used for quantitative variables and Pearson chi-square for categorical values. RESULTS: Osteopenia was present in the hip in 69% and in the lumbar spine in 68%. Most patients had received steroids; the difference between treated and not treated patients was not significant. Osteopenia did not correlate with ileal resection, gender, BMI, disease characteristics or biochemical parameters. CONCLUSIONS: Low bone density was frequent in patients with Crohn's disease, but no specific risk factors could be identified. Bone density should be determined in patients with Crohn's disease in order to institute appropriate therapeutic measures. SN - 0738-0658 UR - https://www.unboundmedicine.com/medline/citation/11293884/Osteopenia_in_Puerto_Ricans_with_Crohn's_disease_ L2 - http://www.diseaseinfosearch.org/result/2013 DB - PRIME DP - Unbound Medicine ER -