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Studies on a fraction of human gastric mucosa containing intrinsic factor isoproteins typical of mucosa.
Scand J Clin Lab Invest. 1975 Jan; 35(1):13-8.SJ

Abstract

A mucosal fraction containing isoproteins of the vitamin B12-intrinsic factor complex with high isoelectric points (pH 5.95-6.52) was prepared, using DEAE-cellulose chromatography. It possessed biological and immunological intrinsic factor activity, and its molecular weight was about 2,000 daltons smaller than that of the isoprotein assembly of gastric juice. Neuraminidase digestion of the gastric juice complex produced a biologically active product containing the high pI isoproteins typical of mucosa. Thus the high pI fraction is deficient in sialic acid, apparently consisting of 'incomplete' molecules not yet ready to be secreted.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1129589

Citation

Gräsbeck, R, and G Marcoullis. "Studies On a Fraction of Human Gastric Mucosa Containing Intrinsic Factor Isoproteins Typical of Mucosa." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 35, no. 1, 1975, pp. 13-8.
Gräsbeck R, Marcoullis G. Studies on a fraction of human gastric mucosa containing intrinsic factor isoproteins typical of mucosa. Scand J Clin Lab Invest. 1975;35(1):13-8.
Gräsbeck, R., & Marcoullis, G. (1975). Studies on a fraction of human gastric mucosa containing intrinsic factor isoproteins typical of mucosa. Scandinavian Journal of Clinical and Laboratory Investigation, 35(1), 13-8.
Gräsbeck R, Marcoullis G. Studies On a Fraction of Human Gastric Mucosa Containing Intrinsic Factor Isoproteins Typical of Mucosa. Scand J Clin Lab Invest. 1975;35(1):13-8. PubMed PMID: 1129589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on a fraction of human gastric mucosa containing intrinsic factor isoproteins typical of mucosa. AU - Gräsbeck,R, AU - Marcoullis,G, PY - 1975/1/1/pubmed PY - 1975/1/1/medline PY - 1975/1/1/entrez SP - 13 EP - 8 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 35 IS - 1 N2 - A mucosal fraction containing isoproteins of the vitamin B12-intrinsic factor complex with high isoelectric points (pH 5.95-6.52) was prepared, using DEAE-cellulose chromatography. It possessed biological and immunological intrinsic factor activity, and its molecular weight was about 2,000 daltons smaller than that of the isoprotein assembly of gastric juice. Neuraminidase digestion of the gastric juice complex produced a biologically active product containing the high pI isoproteins typical of mucosa. Thus the high pI fraction is deficient in sialic acid, apparently consisting of 'incomplete' molecules not yet ready to be secreted. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/1129589/Studies_on_a_fraction_of_human_gastric_mucosa_containing_intrinsic_factor_isoproteins_typical_of_mucosa_ DB - PRIME DP - Unbound Medicine ER -