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Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B-cell lymphoma.
Arch Dermatol. 2001 Apr; 137(4):432-9.AD

Abstract

OBJECTIVE

To determine the clinicopathologic, immunophenotypic, and molecular characteristics of primary follicular cutaneous B-cell lymphoma (CBCL) as defined by the revised European-American lymphoma classification.

DESIGN

A retrospective survey of the medical records, an immunohistochemical study of archival biopsy specimens. and molecular studies of preserved DNA of all patients with follicle center lymphoma-follicular (FCL-F) primary CBCL from 1987 to 1997.

SETTING

A single-center outpatient specialty clinic at an academic medical center.

PATIENTS

Twenty-one patients (68% of all new primary CBCL cases), including 14 men and 7 women (age range, 33-88 years; mean, 55 years).

RESULTS

The head and neck region was the most frequent primary site. Following treatment, recurrences were relatively frequent, but the overall mortality rate during 1.0 to 11.3 years (mean, 6.3 years) of follow-up was 4.8%. Immunohistochemical analysis for B- and T-cell lineages was helpful in enhancing the folliclelike structures. CD10, bcl-2, and CD43 were expressed by the neoplastic cells in 9 (47%) of 19 cases, 4 (21%) of 19 cases, and 2 (13%) of 16 cases, respectively. Immunohistochemical detection of cytoplasmic immunoglobulin light chains, using steaming in EDTA as the antigen-retrieval technique, was successful in 12 (71%) of 17 cases. The Ig heavy-chain gene rearrangements, using the Southern blot technique, detected clonality in 17 (94%) of 18 cases. The bcl-2 gene rearrangements were detected in only 2 (13%) of 15 of the primary cutaneous FCL-F cases, compared with 9 (75%) of 12 of the primary nodal FCL-F cases (P =.002).

CONCLUSIONS

Primary cutaneous FCL-F is a relatively common subtype of CBCL, with a relatively indolent course. It has many features in common with primary nodal FCL-F, except for low rates of bcl-2 expression and bcl-2 gene rearrangements.

Authors+Show Affiliations

Department of Dermatology, Rambam Medical Center, POB 9602, 31096 Haifa, Israel. dermatology@rambam.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

11295923

Citation

Bergman, R, et al. "Clinicopathologic, Immunophenotypic, and Molecular Characterization of Primary Cutaneous Follicular B-cell Lymphoma." Archives of Dermatology, vol. 137, no. 4, 2001, pp. 432-9.
Bergman R, Kurtin PJ, Gibson LE, et al. Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B-cell lymphoma. Arch Dermatol. 2001;137(4):432-9.
Bergman, R., Kurtin, P. J., Gibson, L. E., Hull, P. R., Kimlinger, T. K., & Schroeter, A. L. (2001). Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B-cell lymphoma. Archives of Dermatology, 137(4), 432-9.
Bergman R, et al. Clinicopathologic, Immunophenotypic, and Molecular Characterization of Primary Cutaneous Follicular B-cell Lymphoma. Arch Dermatol. 2001;137(4):432-9. PubMed PMID: 11295923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B-cell lymphoma. AU - Bergman,R, AU - Kurtin,P J, AU - Gibson,L E, AU - Hull,P R, AU - Kimlinger,T K, AU - Schroeter,A L, PY - 2001/5/1/pubmed PY - 2001/5/5/medline PY - 2001/5/1/entrez SP - 432 EP - 9 JF - Archives of dermatology JO - Arch Dermatol VL - 137 IS - 4 N2 - OBJECTIVE: To determine the clinicopathologic, immunophenotypic, and molecular characteristics of primary follicular cutaneous B-cell lymphoma (CBCL) as defined by the revised European-American lymphoma classification. DESIGN: A retrospective survey of the medical records, an immunohistochemical study of archival biopsy specimens. and molecular studies of preserved DNA of all patients with follicle center lymphoma-follicular (FCL-F) primary CBCL from 1987 to 1997. SETTING: A single-center outpatient specialty clinic at an academic medical center. PATIENTS: Twenty-one patients (68% of all new primary CBCL cases), including 14 men and 7 women (age range, 33-88 years; mean, 55 years). RESULTS: The head and neck region was the most frequent primary site. Following treatment, recurrences were relatively frequent, but the overall mortality rate during 1.0 to 11.3 years (mean, 6.3 years) of follow-up was 4.8%. Immunohistochemical analysis for B- and T-cell lineages was helpful in enhancing the folliclelike structures. CD10, bcl-2, and CD43 were expressed by the neoplastic cells in 9 (47%) of 19 cases, 4 (21%) of 19 cases, and 2 (13%) of 16 cases, respectively. Immunohistochemical detection of cytoplasmic immunoglobulin light chains, using steaming in EDTA as the antigen-retrieval technique, was successful in 12 (71%) of 17 cases. The Ig heavy-chain gene rearrangements, using the Southern blot technique, detected clonality in 17 (94%) of 18 cases. The bcl-2 gene rearrangements were detected in only 2 (13%) of 15 of the primary cutaneous FCL-F cases, compared with 9 (75%) of 12 of the primary nodal FCL-F cases (P =.002). CONCLUSIONS: Primary cutaneous FCL-F is a relatively common subtype of CBCL, with a relatively indolent course. It has many features in common with primary nodal FCL-F, except for low rates of bcl-2 expression and bcl-2 gene rearrangements. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/11295923/Clinicopathologic_immunophenotypic_and_molecular_characterization_of_primary_cutaneous_follicular_B_cell_lymphoma_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/137/pg/432 DB - PRIME DP - Unbound Medicine ER -