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[Polyneuropathy index-revised in the evaluation of diabetic neuropathy].
No To Shinkei. 2001 Mar; 53(3):259-63.NT

Abstract

The polyneuropathy index-revised(PNI-R), based on 8 electrophysiological parameters(conduction velocities and F-latencies), was constructed to obtain an overall estimation of peripheral nerve conduction in diabetic patients, taking PNI as a model. PNI was calculated as a mean percentage of the normal on 12 velocity or latency parameters on motor nerve conduction studies. PNI-R is composed of 8 parameters; motor nerve conduction velocities in the forearm or leg segment and F-wave latencies after wrist or ankle stimulation concerning to the median, ulnar, peroneal and posterior tibial nerves. F-wave latencies were adjusted to 160 cm height and used reciprocals to compare with the normal values. Subjects were 101 patients with diabetes mellitus. Correlation of PNI-R or PNI with other parameters or indices on conventional sensory and intrafascicular conduction studies or items concerning to the diabetes mellitus were studied. Coefficient of correlation between PNI-R and PNI was as high as 0.97. The mean value of PNI-R was 0.6% smaller than PNI. This was presumably due to the greater influence of the peroneal parameters, weighted more in PNI-R than in PNI. Peroneal nerve is known to be sensitive to various neuropathies, and is often damaged independently. Each parameter composing PNI-R had a close relationship with PNI-R itself. Mutual independence between 8 parameters was considered to be enough. Among neuropathic signs Achilles tendon reflex in particular, and among diabetic complications retinopathy in particular, had a high degree of correlation with PNI-R. These results were identical both with PNI-R and PNI. We can save 20-30% of time in measuring PNI-R as compared to measure PNI, and the usefulness of PNI-R was as well as PNI. Therefore, using PNI-R as substitute for PNI is considered to be appropriate in the evaluation of diabetic polyneuropathy. Between parameters concerning to the median nerve F-wave latency correlated less with PNI-R than motor nerve conduction velocity in the forearm segment. Presumably this was owing to an unrecognized subclinical carpal tunnel syndrome, often observed in patients with diabetes mellitus. PNI-R will be an excellent index to express the function of peripheral nerve conduction, which can be retarded by the axonal degeneration in diabetes mellitus.

Authors+Show Affiliations

Division of Medical Risk Management, Yokohama City University Medical Center, Yokohama.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

11296400

Citation

Hasegawa, O, et al. "[Polyneuropathy Index-revised in the Evaluation of Diabetic Neuropathy]." No to Shinkei = Brain and Nerve, vol. 53, no. 3, 2001, pp. 259-63.
Hasegawa O, Matsumoto S, Gondo G, et al. [Polyneuropathy index-revised in the evaluation of diabetic neuropathy]. No To Shinkei. 2001;53(3):259-63.
Hasegawa, O., Matsumoto, S., Gondo, G., & Arita, T. (2001). [Polyneuropathy index-revised in the evaluation of diabetic neuropathy]. No to Shinkei = Brain and Nerve, 53(3), 259-63.
Hasegawa O, et al. [Polyneuropathy Index-revised in the Evaluation of Diabetic Neuropathy]. No To Shinkei. 2001;53(3):259-63. PubMed PMID: 11296400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Polyneuropathy index-revised in the evaluation of diabetic neuropathy]. AU - Hasegawa,O, AU - Matsumoto,S, AU - Gondo,G, AU - Arita,T, PY - 2001/4/12/pubmed PY - 2001/5/25/medline PY - 2001/4/12/entrez SP - 259 EP - 63 JF - No to shinkei = Brain and nerve JO - No To Shinkei VL - 53 IS - 3 N2 - The polyneuropathy index-revised(PNI-R), based on 8 electrophysiological parameters(conduction velocities and F-latencies), was constructed to obtain an overall estimation of peripheral nerve conduction in diabetic patients, taking PNI as a model. PNI was calculated as a mean percentage of the normal on 12 velocity or latency parameters on motor nerve conduction studies. PNI-R is composed of 8 parameters; motor nerve conduction velocities in the forearm or leg segment and F-wave latencies after wrist or ankle stimulation concerning to the median, ulnar, peroneal and posterior tibial nerves. F-wave latencies were adjusted to 160 cm height and used reciprocals to compare with the normal values. Subjects were 101 patients with diabetes mellitus. Correlation of PNI-R or PNI with other parameters or indices on conventional sensory and intrafascicular conduction studies or items concerning to the diabetes mellitus were studied. Coefficient of correlation between PNI-R and PNI was as high as 0.97. The mean value of PNI-R was 0.6% smaller than PNI. This was presumably due to the greater influence of the peroneal parameters, weighted more in PNI-R than in PNI. Peroneal nerve is known to be sensitive to various neuropathies, and is often damaged independently. Each parameter composing PNI-R had a close relationship with PNI-R itself. Mutual independence between 8 parameters was considered to be enough. Among neuropathic signs Achilles tendon reflex in particular, and among diabetic complications retinopathy in particular, had a high degree of correlation with PNI-R. These results were identical both with PNI-R and PNI. We can save 20-30% of time in measuring PNI-R as compared to measure PNI, and the usefulness of PNI-R was as well as PNI. Therefore, using PNI-R as substitute for PNI is considered to be appropriate in the evaluation of diabetic polyneuropathy. Between parameters concerning to the median nerve F-wave latency correlated less with PNI-R than motor nerve conduction velocity in the forearm segment. Presumably this was owing to an unrecognized subclinical carpal tunnel syndrome, often observed in patients with diabetes mellitus. PNI-R will be an excellent index to express the function of peripheral nerve conduction, which can be retarded by the axonal degeneration in diabetes mellitus. SN - 0006-8969 UR - https://www.unboundmedicine.com/medline/citation/11296400/[Polyneuropathy_index_revised_in_the_evaluation_of_diabetic_neuropathy]_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -