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Arterialization of the liver in combination with a portacaval shunt in the dog.
Surg Gynecol Obstet. 1975 Apr; 140(4):594-600.SG

Abstract

A dog preparation has been developed combining an end-to-side portacaval shunt with arterialization of the hepatic portion of the portal vein through an anastomosis between the inferior branch of the splenic artery and the stump of the portal vein. In this dog preparation, total hepatic blood flow, perfusion of the intrahepatic portal vein, and sinusoidal pressure remained within the preoperative range in the majority of the dogs. The data presented indicate that arterialization of the liver, under those conditions, resulted in no histologic damage or atrophy of the parenchyma of the liver and was effective in achieving significant prolongation of life and prevention of most of the adverse metabolic sequelae that follow a portacaval shunt in dogs. The indocyanine green extraction was restored to normal. The extraction of ammonia was impaired in all dogs with shunts; however, a significantly better ammonia extraction was seen in dogs with arterialization of the liver. It is being postulated that the dual perfusion of the liver through the hepatic artery and the portal vein is essential for the maintenance of the normal morphologic and functional states of the liver in dogs. The avoidance of hyperfusion of the sinusoidal bed with arterial blood is the most critical factor in preventing morphologic damage of the liver if arterialization of the portal vein is used.

Authors

Adamsons RJ
No affiliation info available
Arif S
No affiliation info available
Babich A
No affiliation info available
Butt K
No affiliation info available
Lam A
No affiliation info available
Minkowitz S
No affiliation info available

MeSH

AmmoniaAmmonium ChlorideAnimalsArteriovenous Shunt, SurgicalBiopsy, NeedleBody WeightBrain DiseasesDogsHepatic VeinsIndocyanine GreenLiverLiver CirculationPortacaval Shunt, SurgicalPortal VeinRegional Blood FlowSplenectomySplenic ArteryTime FactorsVenous Pressure

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1129667

Citation

Adamsons, R J., et al. "Arterialization of the Liver in Combination With a Portacaval Shunt in the Dog." Surgery, Gynecology & Obstetrics, vol. 140, no. 4, 1975, pp. 594-600.
Adamsons RJ, Arif S, Babich A, et al. Arterialization of the liver in combination with a portacaval shunt in the dog. Surg Gynecol Obstet. 1975;140(4):594-600.
Adamsons, R. J., Arif, S., Babich, A., Butt, K., Lam, A., & Minkowitz, S. (1975). Arterialization of the liver in combination with a portacaval shunt in the dog. Surgery, Gynecology & Obstetrics, 140(4), 594-600.
Adamsons RJ, et al. Arterialization of the Liver in Combination With a Portacaval Shunt in the Dog. Surg Gynecol Obstet. 1975;140(4):594-600. PubMed PMID: 1129667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Arterialization of the liver in combination with a portacaval shunt in the dog. AU - Adamsons,R J, AU - Arif,S, AU - Babich,A, AU - Butt,K, AU - Lam,A, AU - Minkowitz,S, PY - 1975/4/1/pubmed PY - 1975/4/1/medline PY - 1975/4/1/entrez SP - 594 EP - 600 JF - Surgery, gynecology & obstetrics JO - Surg Gynecol Obstet VL - 140 IS - 4 N2 - A dog preparation has been developed combining an end-to-side portacaval shunt with arterialization of the hepatic portion of the portal vein through an anastomosis between the inferior branch of the splenic artery and the stump of the portal vein. In this dog preparation, total hepatic blood flow, perfusion of the intrahepatic portal vein, and sinusoidal pressure remained within the preoperative range in the majority of the dogs. The data presented indicate that arterialization of the liver, under those conditions, resulted in no histologic damage or atrophy of the parenchyma of the liver and was effective in achieving significant prolongation of life and prevention of most of the adverse metabolic sequelae that follow a portacaval shunt in dogs. The indocyanine green extraction was restored to normal. The extraction of ammonia was impaired in all dogs with shunts; however, a significantly better ammonia extraction was seen in dogs with arterialization of the liver. It is being postulated that the dual perfusion of the liver through the hepatic artery and the portal vein is essential for the maintenance of the normal morphologic and functional states of the liver in dogs. The avoidance of hyperfusion of the sinusoidal bed with arterial blood is the most critical factor in preventing morphologic damage of the liver if arterialization of the portal vein is used. SN - 0039-6087 UR - https://www.unboundmedicine.com/medline/citation/1129667/Arterialization_of_the_liver_in_combination_with_a_portacaval_shunt_in_the_dog_ DB - PRIME DP - Unbound Medicine ER -