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Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes.
J Rheumatol. 2001 Mar; 28(3):571-6.JR

Abstract

OBJECTIVE

To explore gender differences in the relationship of serum uric acid levels with fasting serum insulin and fasting plasma glucose concentrations among an adult Chinese nondiabetic population in Kinmen, Taiwan.

METHODS

A total of 7,483 nondiabetic subjects (4,265 women, 3,218 men, aged 30 to 89 years) were involved in a community based epidemiologic study. Those with known or newly diagnosed diabetes were excluded. Overnight fasting blood samples were drawn for serum uric acid, glucose, insulin, lipid, and other biochemical measurements. Demographic and clinical variables including body mass index (weight/height2), waist-to-hip ratio, and blood pressure were measured and documented during face-to-face interviews with structured questionnaires.

RESULTS

Stratified analyses revealed that (1) serum uric acid levels were positively associated with hyperinsulinemia and HOMA-insulin resistance in both men and women after adjusting for hypertriglyceridemia, hypertension, obesity, and plasma glucose levels; and (2) serum uric acid levels were more strongly associated with hyperinsulinemia and plasma glucose levels in women than in men. CONCLUSION; Hyperuricemia was positively associated with hyperinsulinemia among patients of both sexes without diabetes. Elevated levels of uric acid should alert physicians to the possibility of insulin resistance. The serum uric acid level was associated with insulin resistance and plasma glucose levels more strongly in females than in males in our study population.

Authors+Show Affiliations

Chou P
Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan.
Lin KC
No affiliation info available
Lin HY
No affiliation info available
Tsai ST
No affiliation info available

MeSH

AdultAgedAged, 80 and overBiomarkersBlood GlucoseBody Mass IndexDiabetes MellitusFastingFemaleHumansHyperinsulinismInsulinInsulin ResistanceMaleMiddle AgedRegression AnalysisSex CharacteristicsUric Acid

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11296961

Citation

Chou, P, et al. "Gender Differences in the Relationships of Serum Uric Acid With Fasting Serum Insulin and Plasma Glucose in Patients Without Diabetes." The Journal of Rheumatology, vol. 28, no. 3, 2001, pp. 571-6.
Chou P, Lin KC, Lin HY, et al. Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. J Rheumatol. 2001;28(3):571-6.
Chou, P., Lin, K. C., Lin, H. Y., & Tsai, S. T. (2001). Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. The Journal of Rheumatology, 28(3), 571-6.
Chou P, et al. Gender Differences in the Relationships of Serum Uric Acid With Fasting Serum Insulin and Plasma Glucose in Patients Without Diabetes. J Rheumatol. 2001;28(3):571-6. PubMed PMID: 11296961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gender differences in the relationships of serum uric acid with fasting serum insulin and plasma glucose in patients without diabetes. AU - Chou,P, AU - Lin,K C, AU - Lin,H Y, AU - Tsai,S T, PY - 2001/4/12/pubmed PY - 2001/7/6/medline PY - 2001/4/12/entrez SP - 571 EP - 6 JF - The Journal of rheumatology JO - J Rheumatol VL - 28 IS - 3 N2 - OBJECTIVE: To explore gender differences in the relationship of serum uric acid levels with fasting serum insulin and fasting plasma glucose concentrations among an adult Chinese nondiabetic population in Kinmen, Taiwan. METHODS: A total of 7,483 nondiabetic subjects (4,265 women, 3,218 men, aged 30 to 89 years) were involved in a community based epidemiologic study. Those with known or newly diagnosed diabetes were excluded. Overnight fasting blood samples were drawn for serum uric acid, glucose, insulin, lipid, and other biochemical measurements. Demographic and clinical variables including body mass index (weight/height2), waist-to-hip ratio, and blood pressure were measured and documented during face-to-face interviews with structured questionnaires. RESULTS: Stratified analyses revealed that (1) serum uric acid levels were positively associated with hyperinsulinemia and HOMA-insulin resistance in both men and women after adjusting for hypertriglyceridemia, hypertension, obesity, and plasma glucose levels; and (2) serum uric acid levels were more strongly associated with hyperinsulinemia and plasma glucose levels in women than in men. CONCLUSION; Hyperuricemia was positively associated with hyperinsulinemia among patients of both sexes without diabetes. Elevated levels of uric acid should alert physicians to the possibility of insulin resistance. The serum uric acid level was associated with insulin resistance and plasma glucose levels more strongly in females than in males in our study population. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/11296961/Gender_differences_in_the_relationships_of_serum_uric_acid_with_fasting_serum_insulin_and_plasma_glucose_in_patients_without_diabetes_ DB - PRIME DP - Unbound Medicine ER -