Tags

Type your tag names separated by a space and hit enter

Macular pigment optical density in a midwestern sample.
Ophthalmology. 2001 Apr; 108(4):730-7.O

Abstract

OBJECTIVE

To assess the distribution of the macular pigments (MPs) lutein (L) and zeaxanthin (Z) in a healthy sample more representative of the general population than past studies and to determine which dietary factors and personal characteristics might explain the large interindividual differences in the density of these MPs.

DESIGN

Prevalence study in a self-selected population.

PARTICIPANTS

Two hundred eighty healthy adult volunteers, consisting of 138 men and 142 women, between the ages of 18 and 50 years, recruited from the general population.

METHODS

MP optical density was measured psychophysically at 460 nm by use of a 1 degrees test field. Serum was analyzed for carotenoid and vitamin E content with reversed-phase high-performance liquid chromatography. Usual intakes of nutrients over the past year were determined by means of a food frequency questionnaire.

MAIN OUTCOME MEASURES

MP optical density.

RESULTS

Mean MP optical density measured 0.211 +/- 0.13, which is approximately 40% lower than the average reported in smaller, less representative studies. MP density was 44% lower in the bottom versus the top quintile of serum L and Z concentrations. Similarly, MP density was 33% lower in the bottom compared with the top quintile of L and Z intake. MP density was 19% lower in blue-grey-eyed subjects than in subjects with brown-black irises. When all variables were considered together in a general linear model of determinants of MP, statistically significant (P < 0.05) relationships were found between MP density and serum L and Z, dietary L and Z intake, fiber intake, and iris color.

CONCLUSIONS

These data suggest that MP values in this healthy adult population are lower than in smaller select samples. Moreover, these data indicate that MP is related to serum L and Z, dietary L and Z intake, fiber intake, and iris color.

Authors+Show Affiliations

Retina Service, Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46260, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11297490

Citation

Ciulla, T A., et al. "Macular Pigment Optical Density in a Midwestern Sample." Ophthalmology, vol. 108, no. 4, 2001, pp. 730-7.
Ciulla TA, Curran-Celantano J, Cooper DA, et al. Macular pigment optical density in a midwestern sample. Ophthalmology. 2001;108(4):730-7.
Ciulla, T. A., Curran-Celantano, J., Cooper, D. A., Hammond, B. R., Danis, R. P., Pratt, L. M., Riccardi, K. A., & Filloon, T. G. (2001). Macular pigment optical density in a midwestern sample. Ophthalmology, 108(4), 730-7.
Ciulla TA, et al. Macular Pigment Optical Density in a Midwestern Sample. Ophthalmology. 2001;108(4):730-7. PubMed PMID: 11297490.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular pigment optical density in a midwestern sample. AU - Ciulla,T A, AU - Curran-Celantano,J, AU - Cooper,D A, AU - Hammond,B R,Jr AU - Danis,R P, AU - Pratt,L M, AU - Riccardi,K A, AU - Filloon,T G, PY - 2001/4/12/pubmed PY - 2001/4/21/medline PY - 2001/4/12/entrez SP - 730 EP - 7 JF - Ophthalmology JO - Ophthalmology VL - 108 IS - 4 N2 - OBJECTIVE: To assess the distribution of the macular pigments (MPs) lutein (L) and zeaxanthin (Z) in a healthy sample more representative of the general population than past studies and to determine which dietary factors and personal characteristics might explain the large interindividual differences in the density of these MPs. DESIGN: Prevalence study in a self-selected population. PARTICIPANTS: Two hundred eighty healthy adult volunteers, consisting of 138 men and 142 women, between the ages of 18 and 50 years, recruited from the general population. METHODS: MP optical density was measured psychophysically at 460 nm by use of a 1 degrees test field. Serum was analyzed for carotenoid and vitamin E content with reversed-phase high-performance liquid chromatography. Usual intakes of nutrients over the past year were determined by means of a food frequency questionnaire. MAIN OUTCOME MEASURES: MP optical density. RESULTS: Mean MP optical density measured 0.211 +/- 0.13, which is approximately 40% lower than the average reported in smaller, less representative studies. MP density was 44% lower in the bottom versus the top quintile of serum L and Z concentrations. Similarly, MP density was 33% lower in the bottom compared with the top quintile of L and Z intake. MP density was 19% lower in blue-grey-eyed subjects than in subjects with brown-black irises. When all variables were considered together in a general linear model of determinants of MP, statistically significant (P < 0.05) relationships were found between MP density and serum L and Z, dietary L and Z intake, fiber intake, and iris color. CONCLUSIONS: These data suggest that MP values in this healthy adult population are lower than in smaller select samples. Moreover, these data indicate that MP is related to serum L and Z, dietary L and Z intake, fiber intake, and iris color. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/11297490/Macular_pigment_optical_density_in_a_midwestern_sample_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(00)00655-2 DB - PRIME DP - Unbound Medicine ER -