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[Olav Egeberg--hereditary antithrombin deficiency and thrombophilia].
Tidsskr Nor Laegeforen. 2001 Feb 20; 121(5):604-5.TN

Abstract

In 1965 Olav Egeberg (1916-77) presented the first report that linked a defined, hereditary defect in the control of blood coagulation to thrombotic disease. Having examined a family in which several members had sustained venous thrombosis, he demonstrated that antithrombin activity was clearly subnormal in the affected members. Heparin cofactor activity was also subnormal in these persons. This supported the hypothesis that the two activities might reside in a single protein. The condition was inherited as an autosomal dominant trait. Egeberg's publication initiated thrombophilia as a rewarding research area, and also as an important clinical discipline.

Authors+Show Affiliations

Medisinsk klinikk, Aker sykehus, 0514 Oslo. ulrich.abildgaard@ioks.uio.no

Pub Type(s)

Biography
Historical Article
Journal Article
Portrait

Language

nor

PubMed ID

11301618

Citation

Abildgaard, U. "[Olav Egeberg--hereditary Antithrombin Deficiency and Thrombophilia]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 121, no. 5, 2001, pp. 604-5.
Abildgaard U. [Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]. Tidsskr Nor Laegeforen. 2001;121(5):604-5.
Abildgaard, U. (2001). [Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 121(5), 604-5.
Abildgaard U. [Olav Egeberg--hereditary Antithrombin Deficiency and Thrombophilia]. Tidsskr Nor Laegeforen. 2001 Feb 20;121(5):604-5. PubMed PMID: 11301618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]. A1 - Abildgaard,U, PY - 2001/4/17/pubmed PY - 2001/5/18/medline PY - 2001/4/17/entrez SP - 604 EP - 5 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr. Nor. Laegeforen. VL - 121 IS - 5 N2 - In 1965 Olav Egeberg (1916-77) presented the first report that linked a defined, hereditary defect in the control of blood coagulation to thrombotic disease. Having examined a family in which several members had sustained venous thrombosis, he demonstrated that antithrombin activity was clearly subnormal in the affected members. Heparin cofactor activity was also subnormal in these persons. This supported the hypothesis that the two activities might reside in a single protein. The condition was inherited as an autosomal dominant trait. Egeberg's publication initiated thrombophilia as a rewarding research area, and also as an important clinical discipline. SN - 0029-2001 UR - https://www.unboundmedicine.com/medline/citation/11301618/[Olav_Egeberg__hereditary_antithrombin_deficiency_and_thrombophilia]_ L2 - http://tidsskriftet.no/article/271450 DB - PRIME DP - Unbound Medicine ER -