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Birth weight and childhood onset type 1 diabetes: population based cohort study.

Abstract

OBJECTIVE

To assess the associations between birth weight or gestational age and risk of type 1 diabetes.

DESIGN

Population based cohort study by record linkage of the medical birth registry and the National Childhood Diabetes Registry.

SETTING

Two national registries in Norway.

PARTICIPANTS

All live births in Norway between 1974 and 1998 (1 382 602 individuals) contributed a maximum of 15 years of observation, a total of 8 184 994 person years of observation in the period 1989 to 1998. 1824 children with type 1 diabetes were diagnosed between 1989 and 1998.

MAIN OUTCOME MEASURES

Estimates of rate ratios with 95% confidence intervals for type 1 diabetes from Poisson regression analyses.

RESULTS

The incidence rate of type 1 diabetes increased almost linearly with birth weight. The rate ratio for children with birth weights 4500 g or more compared with those with birth weights less than 2000 g was 2.21 (95% confidence interval 1.24 to 3.94), test for trend P=0.0001. There was no significant association between gestational age and type 1 diabetes. The results persisted after adjustment for maternal diabetes and other potential confounders.

CONCLUSION

There is a relatively weak but significant association between birth weight and increased risk of type 1 diabetes consistent over a wide range of birth weights.

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  • Authors+Show Affiliations

    ,

    Section of Epidemiology, Department of Population Health Sciences, National Institute of Public Health, Nydalen, N-0403 Oslo, Norway. lars.christian.stene@folkehelsa.no

    , , , ,

    Source

    BMJ (Clinical research ed.) 322:7291 2001 Apr 14 pg 889-92

    MeSH

    Adolescent
    Birth Weight
    Child
    Child, Preschool
    Cohort Studies
    Diabetes Mellitus, Type 1
    Female
    Gestational Age
    Humans
    Incidence
    Infant
    Male
    Norway
    Regression Analysis
    Risk Factors
    Sex Distribution

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    11302899

    Citation

    Stene, L C., et al. "Birth Weight and Childhood Onset Type 1 Diabetes: Population Based Cohort Study." BMJ (Clinical Research Ed.), vol. 322, no. 7291, 2001, pp. 889-92.
    Stene LC, Magnus P, Lie RT, et al. Birth weight and childhood onset type 1 diabetes: population based cohort study. BMJ. 2001;322(7291):889-92.
    Stene, L. C., Magnus, P., Lie, R. T., Søvik, O., & Joner, G. (2001). Birth weight and childhood onset type 1 diabetes: population based cohort study. BMJ (Clinical Research Ed.), 322(7291), pp. 889-92.
    Stene LC, et al. Birth Weight and Childhood Onset Type 1 Diabetes: Population Based Cohort Study. BMJ. 2001 Apr 14;322(7291):889-92. PubMed PMID: 11302899.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Birth weight and childhood onset type 1 diabetes: population based cohort study. AU - Stene,L C, AU - Magnus,P, AU - Lie,R T, AU - Søvik,O, AU - Joner,G, AU - ,, PY - 2001/4/17/pubmed PY - 2001/5/18/medline PY - 2001/4/17/entrez SP - 889 EP - 92 JF - BMJ (Clinical research ed.) JO - BMJ VL - 322 IS - 7291 N2 - OBJECTIVE: To assess the associations between birth weight or gestational age and risk of type 1 diabetes. DESIGN: Population based cohort study by record linkage of the medical birth registry and the National Childhood Diabetes Registry. SETTING: Two national registries in Norway. PARTICIPANTS: All live births in Norway between 1974 and 1998 (1 382 602 individuals) contributed a maximum of 15 years of observation, a total of 8 184 994 person years of observation in the period 1989 to 1998. 1824 children with type 1 diabetes were diagnosed between 1989 and 1998. MAIN OUTCOME MEASURES: Estimates of rate ratios with 95% confidence intervals for type 1 diabetes from Poisson regression analyses. RESULTS: The incidence rate of type 1 diabetes increased almost linearly with birth weight. The rate ratio for children with birth weights 4500 g or more compared with those with birth weights less than 2000 g was 2.21 (95% confidence interval 1.24 to 3.94), test for trend P=0.0001. There was no significant association between gestational age and type 1 diabetes. The results persisted after adjustment for maternal diabetes and other potential confounders. CONCLUSION: There is a relatively weak but significant association between birth weight and increased risk of type 1 diabetes consistent over a wide range of birth weights. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/11302899/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&pmid=11302899 DB - PRIME DP - Unbound Medicine ER -