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Stereopsis in patients with albinism: clinical correlates.
J AAPOS. 2001 Apr; 5(2):98-104.JA

Abstract

PURPOSE

A hallmark of albinism is excessive decussation of retinostriate projections at the optic chiasm. This misprojection might lead to abnormalities in the retinal correspondence and may account for the usual absence of stereovision. We report on 2 groups of patients with albinism who have either fine or gross stereopsis and compare the clinical findings of these groups to other patients with albinism with similar visual acuities but no stereopsis.

METHODS

A retrospective chart review of patients with albinism was used to segregate those with a letter visual acuity of 20/100 or better in one eye, assessment of stereopsis, and strabismus < or = 10 PD. Forty-five patients were identified. Albinism type, best-corrected visual acuity, motility, Titmus vectograph stereoacuity, iris and macula transparency grades, and the presence or absence of both melanin and an annular reflex in the macula were tabulated. A comparison of the clinical characteristics of the groups with and without stereopsis was made.

RESULTS

Those albino subjects who demonstrated stereopsis had better visual acuity, less iris transillumination, more frequent presence of melanin in the macula, less nystagmus, and less marked foveal hypoplasia than the albino subjects without stereopsis. No nystagmus was clinically detected in 5 patients with fine stereopsis. All these differences were statistically significant. Macular transparency grade was not significantly different between the groups.

CONCLUSIONS

Patients with albinism who demonstrate stereopsis tend to have better visual acuity, more iris pigment, and more melanin pigment in the macula than their counterparts without stereopsis.

Authors+Show Affiliations

Department of Ophthalmology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11304818

Citation

Lee, K A., et al. "Stereopsis in Patients With Albinism: Clinical Correlates." Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, vol. 5, no. 2, 2001, pp. 98-104.
Lee KA, King RA, Summers CG. Stereopsis in patients with albinism: clinical correlates. J AAPOS. 2001;5(2):98-104.
Lee, K. A., King, R. A., & Summers, C. G. (2001). Stereopsis in patients with albinism: clinical correlates. Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus, 5(2), 98-104.
Lee KA, King RA, Summers CG. Stereopsis in Patients With Albinism: Clinical Correlates. J AAPOS. 2001;5(2):98-104. PubMed PMID: 11304818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stereopsis in patients with albinism: clinical correlates. AU - Lee,K A, AU - King,R A, AU - Summers,C G, PY - 2001/4/17/pubmed PY - 2001/6/2/medline PY - 2001/4/17/entrez SP - 98 EP - 104 JF - Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus JO - J AAPOS VL - 5 IS - 2 N2 - PURPOSE: A hallmark of albinism is excessive decussation of retinostriate projections at the optic chiasm. This misprojection might lead to abnormalities in the retinal correspondence and may account for the usual absence of stereovision. We report on 2 groups of patients with albinism who have either fine or gross stereopsis and compare the clinical findings of these groups to other patients with albinism with similar visual acuities but no stereopsis. METHODS: A retrospective chart review of patients with albinism was used to segregate those with a letter visual acuity of 20/100 or better in one eye, assessment of stereopsis, and strabismus < or = 10 PD. Forty-five patients were identified. Albinism type, best-corrected visual acuity, motility, Titmus vectograph stereoacuity, iris and macula transparency grades, and the presence or absence of both melanin and an annular reflex in the macula were tabulated. A comparison of the clinical characteristics of the groups with and without stereopsis was made. RESULTS: Those albino subjects who demonstrated stereopsis had better visual acuity, less iris transillumination, more frequent presence of melanin in the macula, less nystagmus, and less marked foveal hypoplasia than the albino subjects without stereopsis. No nystagmus was clinically detected in 5 patients with fine stereopsis. All these differences were statistically significant. Macular transparency grade was not significantly different between the groups. CONCLUSIONS: Patients with albinism who demonstrate stereopsis tend to have better visual acuity, more iris pigment, and more melanin pigment in the macula than their counterparts without stereopsis. SN - 1091-8531 UR - https://www.unboundmedicine.com/medline/citation/11304818/Stereopsis_in_patients_with_albinism:_clinical_correlates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1091-8531(01)05371-X DB - PRIME DP - Unbound Medicine ER -