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Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments.
Dermatology. 2001; 202(2):171-6.D

Abstract

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies.

Authors+Show Affiliations

Piérard-Franchimont C
Department of Dermatopathology, University of Liège, Belgium.
Piérard GE
No affiliation info available
Arrese JE
No affiliation info available
De Doncker P
No affiliation info available

MeSH

AdultAgedDermatitis, SeborrheicDermatomycosesDouble-Blind MethodFemaleHair PreparationsHumansKetoconazoleMalasseziaMaleMiddle AgedScalp Dermatoses

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

11306850

Citation

Piérard-Franchimont, C, et al. "Effect of Ketoconazole 1% and 2% Shampoos On Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments." Dermatology (Basel, Switzerland), vol. 202, no. 2, 2001, pp. 171-6.
Piérard-Franchimont C, Piérard GE, Arrese JE, et al. Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments. Dermatology. 2001;202(2):171-6.
Piérard-Franchimont, C., Piérard, G. E., Arrese, J. E., & De Doncker, P. (2001). Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments. Dermatology (Basel, Switzerland), 202(2), 171-6.
Piérard-Franchimont C, et al. Effect of Ketoconazole 1% and 2% Shampoos On Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments. Dermatology. 2001;202(2):171-6. PubMed PMID: 11306850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments. AU - Piérard-Franchimont,C, AU - Piérard,G E, AU - Arrese,J E, AU - De Doncker,P, PY - 2001/4/18/pubmed PY - 2001/7/13/medline PY - 2001/4/18/entrez SP - 171 EP - 6 JF - Dermatology (Basel, Switzerland) JO - Dermatology VL - 202 IS - 2 N2 - Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies. SN - 1018-8665 UR - https://www.unboundmedicine.com/medline/citation/11306850/Effect_of_ketoconazole_1_and_2_shampoos_on_severe_dandruff_and_seborrhoeic_dermatitis:_clinical_squamometric_and_mycological_assessments_ DB - PRIME DP - Unbound Medicine ER -