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Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin.
Neuroendocrinology. 2001 Mar; 73(3):203-14.N

Abstract

While corticotropin-releasing hormone (CRH) is a primary regulator of the hypothalamic-pituitary-adrenal (HPA) axis, the mechanism(s) triggering the release of this corticotropin (ACTH) secretagogue remains unknown. Stressful and appetitive events evoke the release of not only CRH but also of bombesin (BN)-like peptides. Furthermore, CRH antagonists attenuate the endocrine and behavioral effects of BN, suggesting that BN-like peptides may mediate their effects via CRH release. An initial (mapping) study revealed that centrally administered BN (0.25 or 0.5 microg i.c.v.) increased circulating corticosterone and ACTH levels and decreased immunoreactive (ir)-CRH at the nucleus of the solitary tract, ventromedial (VMH) and anterior hypothalamic nuclei, and the central amygdaloid nucleus. Whereas BN treatment decreased ir-vasopressin (AVP) at the VMH, it elevated levels of this peptide in the hypothalamic paraventricular and median eminence/arcuate (Me/Arc) regions. Dynamic, in vivo release experiments (using push-pull perfusion) revealed that BN evoked the release of ir-CRH and ir-AVP from the Me/Arc and increased interstitial levels of these secretagogues at the anterior pituitary. These results suggest that BN-like peptides may regulate certain hypothalamic and extrahypothalamic circuits, including the HPA axis, by affecting regional utilization of ir-CRH and ir-AVP, and/or by provoking the release of these peptides at the Me/Arc, thus increasing their availability downstream at the anterior pituitary and increasing circulating ACTH and corticosterone levels.

Authors+Show Affiliations

School of Psychology, University of Ottawa, Ottawa, Ontario, K1N 6N5, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11307039

Citation

Kent, P, et al. "Central Bombesin Activates the Hypothalamic-pituitary-adrenal Axis. Effects On Regional Levels and Release of Corticotropin-releasing Hormone and Arginine-vasopressin." Neuroendocrinology, vol. 73, no. 3, 2001, pp. 203-14.
Kent P, Anisman H, Merali Z. Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin. Neuroendocrinology. 2001;73(3):203-14.
Kent, P., Anisman, H., & Merali, Z. (2001). Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin. Neuroendocrinology, 73(3), 203-14.
Kent P, Anisman H, Merali Z. Central Bombesin Activates the Hypothalamic-pituitary-adrenal Axis. Effects On Regional Levels and Release of Corticotropin-releasing Hormone and Arginine-vasopressin. Neuroendocrinology. 2001;73(3):203-14. PubMed PMID: 11307039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central bombesin activates the hypothalamic-pituitary-adrenal axis. Effects on regional levels and release of corticotropin-releasing hormone and arginine-vasopressin. AU - Kent,P, AU - Anisman,H, AU - Merali,Z, PY - 2001/4/18/pubmed PY - 2001/6/22/medline PY - 2001/4/18/entrez SP - 203 EP - 14 JF - Neuroendocrinology JO - Neuroendocrinology VL - 73 IS - 3 N2 - While corticotropin-releasing hormone (CRH) is a primary regulator of the hypothalamic-pituitary-adrenal (HPA) axis, the mechanism(s) triggering the release of this corticotropin (ACTH) secretagogue remains unknown. Stressful and appetitive events evoke the release of not only CRH but also of bombesin (BN)-like peptides. Furthermore, CRH antagonists attenuate the endocrine and behavioral effects of BN, suggesting that BN-like peptides may mediate their effects via CRH release. An initial (mapping) study revealed that centrally administered BN (0.25 or 0.5 microg i.c.v.) increased circulating corticosterone and ACTH levels and decreased immunoreactive (ir)-CRH at the nucleus of the solitary tract, ventromedial (VMH) and anterior hypothalamic nuclei, and the central amygdaloid nucleus. Whereas BN treatment decreased ir-vasopressin (AVP) at the VMH, it elevated levels of this peptide in the hypothalamic paraventricular and median eminence/arcuate (Me/Arc) regions. Dynamic, in vivo release experiments (using push-pull perfusion) revealed that BN evoked the release of ir-CRH and ir-AVP from the Me/Arc and increased interstitial levels of these secretagogues at the anterior pituitary. These results suggest that BN-like peptides may regulate certain hypothalamic and extrahypothalamic circuits, including the HPA axis, by affecting regional utilization of ir-CRH and ir-AVP, and/or by provoking the release of these peptides at the Me/Arc, thus increasing their availability downstream at the anterior pituitary and increasing circulating ACTH and corticosterone levels. SN - 0028-3835 UR - https://www.unboundmedicine.com/medline/citation/11307039/Central_bombesin_activates_the_hypothalamic_pituitary_adrenal_axis__Effects_on_regional_levels_and_release_of_corticotropin_releasing_hormone_and_arginine_vasopressin_ L2 - https://www.karger.com?DOI=10.1159/000054637 DB - PRIME DP - Unbound Medicine ER -