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Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms.
J Agric Food Chem. 2001 Mar; 49(3):1546-51.JA

Abstract

Four components of black currant anthocyanins (BCA), delphinidin 3-O-beta-rutinoside (D3R), cyanidin 3-O-beta-rutinoside (C3R), delphinidin 3-O-beta-glucoside (D3G), and cyanidin 3-O-beta-glucoside (C3G), were found to be directly absorbed and distributed to the blood and excreted into urine as the glycosylated forms. In a rat study, following oral administration of purified D3R, C3R, and C3G (800 micromol/kg of body weight), the anthocyanins were detected in the plasma and the C(max) values were 580 +/- 410, 850 +/- 120, and 840 +/- 190 nmol/L, respectively, 0.5-2.0 h after administration. In a human study, when a mixture of BCA [6.24 micromol (3.58 mg) consisting of 2.75 micromol (1.68 mg) of D3R, 2.08 micromol (1.24 mg) of C3R, 1.04 micromol (0.488 mg) of D3G, and 0.37 micromol (0.165 mg) of C3G/kg of body weight)] was orally ingested by eight volunteers, D3R, C3R, D3G, and C3G were detected in the plasma and urine. The plasma C(max) values were 73.4 +/- 35.0, 46.3 +/- 22.5, 22.7 +/- 12.4, and 5.0 +/- 3.7 nmol/L, respectively, 1.25-1.75 h after intake, and the cumulative excretion of the four compounds in urine in the period 0-8 h after intake was 0.11 +/- 0.05% of the dose ingested. These results indicate that 3-O-beta-rutinosyl anthocyanins were directly absorbed and distributed to the blood.

Authors+Show Affiliations

Matsumoto H
Bioscience Laboratories, Meiji Seika Kaisha, Ltd., 5-3-1 Chiyoda, Sakado-shi, Saitama 350-0289, Japan. hitoshi_matsumoto@meiji.co.jp
Inaba H
No affiliation info available
Kishi M
No affiliation info available
Tominaga S
No affiliation info available
Hirayama M
No affiliation info available
Tsuda T
No affiliation info available

MeSH

Administration, OralAdultAnimalsAnthocyaninsHumansIntestinal AbsorptionMaleMetabolic Clearance RateMiddle AgedRatsRats, Wistar

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11312894

Citation

Matsumoto, H, et al. "Orally Administered Delphinidin 3-rutinoside and Cyanidin 3-rutinoside Are Directly Absorbed in Rats and Humans and Appear in the Blood as the Intact Forms." Journal of Agricultural and Food Chemistry, vol. 49, no. 3, 2001, pp. 1546-51.
Matsumoto H, Inaba H, Kishi M, et al. Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. J Agric Food Chem. 2001;49(3):1546-51.
Matsumoto, H., Inaba, H., Kishi, M., Tominaga, S., Hirayama, M., & Tsuda, T. (2001). Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. Journal of Agricultural and Food Chemistry, 49(3), 1546-51.
Matsumoto H, et al. Orally Administered Delphinidin 3-rutinoside and Cyanidin 3-rutinoside Are Directly Absorbed in Rats and Humans and Appear in the Blood as the Intact Forms. J Agric Food Chem. 2001;49(3):1546-51. PubMed PMID: 11312894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms. AU - Matsumoto,H, AU - Inaba,H, AU - Kishi,M, AU - Tominaga,S, AU - Hirayama,M, AU - Tsuda,T, PY - 2001/4/21/pubmed PY - 2001/6/22/medline PY - 2001/4/21/entrez SP - 1546 EP - 51 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 49 IS - 3 N2 - Four components of black currant anthocyanins (BCA), delphinidin 3-O-beta-rutinoside (D3R), cyanidin 3-O-beta-rutinoside (C3R), delphinidin 3-O-beta-glucoside (D3G), and cyanidin 3-O-beta-glucoside (C3G), were found to be directly absorbed and distributed to the blood and excreted into urine as the glycosylated forms. In a rat study, following oral administration of purified D3R, C3R, and C3G (800 micromol/kg of body weight), the anthocyanins were detected in the plasma and the C(max) values were 580 +/- 410, 850 +/- 120, and 840 +/- 190 nmol/L, respectively, 0.5-2.0 h after administration. In a human study, when a mixture of BCA [6.24 micromol (3.58 mg) consisting of 2.75 micromol (1.68 mg) of D3R, 2.08 micromol (1.24 mg) of C3R, 1.04 micromol (0.488 mg) of D3G, and 0.37 micromol (0.165 mg) of C3G/kg of body weight)] was orally ingested by eight volunteers, D3R, C3R, D3G, and C3G were detected in the plasma and urine. The plasma C(max) values were 73.4 +/- 35.0, 46.3 +/- 22.5, 22.7 +/- 12.4, and 5.0 +/- 3.7 nmol/L, respectively, 1.25-1.75 h after intake, and the cumulative excretion of the four compounds in urine in the period 0-8 h after intake was 0.11 +/- 0.05% of the dose ingested. These results indicate that 3-O-beta-rutinosyl anthocyanins were directly absorbed and distributed to the blood. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/11312894/Orally_administered_delphinidin_3_rutinoside_and_cyanidin_3_rutinoside_are_directly_absorbed_in_rats_and_humans_and_appear_in_the_blood_as_the_intact_forms_ DB - PRIME DP - Unbound Medicine ER -