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Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women.
Osteoporos Int 2001; 12(3):199-206OI

Abstract

Weight loss may lead to bone loss but little is known about changes in bone mass during regain of reduced weight. We studied changes in bone mineral density (BMD) and bone mineral content (BMC) during voluntary weight reduction and partial regain. The study consisted of three phases: a 3 month weight reduction with very-low-energy diet (VLED), a 9 month randomized, controlled walking intervention period with two training groups (target energy expenditure 4.2 or 8.4 MJ/week) and a 24-month follow-up. The participants were premenopausal women with a mean body mass index of 34.0 (SD 3.6) kg/m2. Seventy-four of 85 subjects completed the whole study. Total body, lumbar spine, proximal femur and dominant radius BMD and BMC were measured with dual-energy X-ray absorptiometry (DXA). The mean weight loss during VLED was 13.2 (3.4) kg, accompanied by unchanged total body BMC and decreased lumbar, trochanteric and radial BMD (p < 0.05). During months 3-36, an average of 62% of the weight loss was regained, total body BMC decreased and trochanteric BMD increased (p < 0.05). At the end of the study, total body BMC and lumbar and femoral neck BMD were lower than initially (p < 0.05). Weight change throughout the study correlated significantly with the change in radial (r = 0.54), total body (r = 0.39) and trochanteric (r = 0.37) BMD. Exercise-group assignment had no effect on BMD at weight-bearing sites. In conclusion, the observed changes in BMD and BMC during weight reduction and its partial regain were clinically small and partly reversible. More studies are needed to clarify whether the observed weight changes in BMD and BMC are real or are artifacts arising from assumptions, inaccuracies and technical limitations of DXA.

Authors+Show Affiliations

UKK Institute for Health Promotion Research, Tampere, Finland. mikael.fogelholm@helsinki.fiNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11315238

Citation

Fogelholm, G M., et al. "Bone Mineral Density During Reduction, Maintenance and Regain of Body Weight in Premenopausal, Obese Women." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 12, no. 3, 2001, pp. 199-206.
Fogelholm GM, Sievänen HT, Kukkonen-Harjula TK, et al. Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women. Osteoporos Int. 2001;12(3):199-206.
Fogelholm, G. M., Sievänen, H. T., Kukkonen-Harjula, T. K., & Pasanen, M. E. (2001). Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 12(3), pp. 199-206.
Fogelholm GM, et al. Bone Mineral Density During Reduction, Maintenance and Regain of Body Weight in Premenopausal, Obese Women. Osteoporos Int. 2001;12(3):199-206. PubMed PMID: 11315238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women. AU - Fogelholm,G M, AU - Sievänen,H T, AU - Kukkonen-Harjula,T K, AU - Pasanen,M E, PY - 2001/4/24/pubmed PY - 2001/5/26/medline PY - 2001/4/24/entrez SP - 199 EP - 206 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 12 IS - 3 N2 - Weight loss may lead to bone loss but little is known about changes in bone mass during regain of reduced weight. We studied changes in bone mineral density (BMD) and bone mineral content (BMC) during voluntary weight reduction and partial regain. The study consisted of three phases: a 3 month weight reduction with very-low-energy diet (VLED), a 9 month randomized, controlled walking intervention period with two training groups (target energy expenditure 4.2 or 8.4 MJ/week) and a 24-month follow-up. The participants were premenopausal women with a mean body mass index of 34.0 (SD 3.6) kg/m2. Seventy-four of 85 subjects completed the whole study. Total body, lumbar spine, proximal femur and dominant radius BMD and BMC were measured with dual-energy X-ray absorptiometry (DXA). The mean weight loss during VLED was 13.2 (3.4) kg, accompanied by unchanged total body BMC and decreased lumbar, trochanteric and radial BMD (p < 0.05). During months 3-36, an average of 62% of the weight loss was regained, total body BMC decreased and trochanteric BMD increased (p < 0.05). At the end of the study, total body BMC and lumbar and femoral neck BMD were lower than initially (p < 0.05). Weight change throughout the study correlated significantly with the change in radial (r = 0.54), total body (r = 0.39) and trochanteric (r = 0.37) BMD. Exercise-group assignment had no effect on BMD at weight-bearing sites. In conclusion, the observed changes in BMD and BMC during weight reduction and its partial regain were clinically small and partly reversible. More studies are needed to clarify whether the observed weight changes in BMD and BMC are real or are artifacts arising from assumptions, inaccuracies and technical limitations of DXA. SN - 0937-941X UR - https://www.unboundmedicine.com/medline/citation/11315238/Bone_mineral_density_during_reduction_maintenance_and_regain_of_body_weight_in_premenopausal_obese_women_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -