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Immunoglobulins in the human male genitourinary tract.
Ital J Anat Embryol. 1998; 103(4 Suppl 1):229-36.IJ

Abstract

Human male genitourinary tract was processed for the immunohistochemical demonstration of IgG and IgM, in order to verify the presence and the source of these immunoglobulins. Only the epithelia of the prostate gland and urethra showed a marked IgM-immunopositivity, localized in the cytoplasm of apical cells. An intense immunoreactivity for IgG was observed in the apical cells of the vesical epithelium; a less intense immunoreactivity for IgG in the pelvic apical epithelial cells was found. Immunostaining in the ureteric epithelium was absent. Clusters of IgM- and IgG-positive immunocompetent cells were present in the subepithelial layers of the organs observed in our study. This study indicates that IgM, present in mucosal surfaces, derived from an active secretion, as well as secretory IgA, whereas most of the IgG present in the human seminal plasma were probably due to transudation process. Immunoreactivity for IgG in the vesical and pelvic epithelia could depend upon to virus-specific IgG antibodies produced by the mucosa. This in turn can contribute to the total antiviral activity in mucosal secretions.

Authors+Show Affiliations

Department of Cytomorphology, University of Cagliari, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11315953

Citation

Perra, M T., et al. "Immunoglobulins in the Human Male Genitourinary Tract." Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia, vol. 103, no. 4 Suppl 1, 1998, pp. 229-36.
Perra MT, Maxia C, Sirigu P. Immunoglobulins in the human male genitourinary tract. Ital J Anat Embryol. 1998;103(4 Suppl 1):229-36.
Perra, M. T., Maxia, C., & Sirigu, P. (1998). Immunoglobulins in the human male genitourinary tract. Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia, 103(4 Suppl 1), 229-36.
Perra MT, Maxia C, Sirigu P. Immunoglobulins in the Human Male Genitourinary Tract. Ital J Anat Embryol. 1998;103(4 Suppl 1):229-36. PubMed PMID: 11315953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunoglobulins in the human male genitourinary tract. AU - Perra,M T, AU - Maxia,C, AU - Sirigu,P, PY - 2001/4/24/pubmed PY - 2001/5/5/medline PY - 2001/4/24/entrez SP - 229 EP - 36 JF - Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia JO - Ital J Anat Embryol VL - 103 IS - 4 Suppl 1 N2 - Human male genitourinary tract was processed for the immunohistochemical demonstration of IgG and IgM, in order to verify the presence and the source of these immunoglobulins. Only the epithelia of the prostate gland and urethra showed a marked IgM-immunopositivity, localized in the cytoplasm of apical cells. An intense immunoreactivity for IgG was observed in the apical cells of the vesical epithelium; a less intense immunoreactivity for IgG in the pelvic apical epithelial cells was found. Immunostaining in the ureteric epithelium was absent. Clusters of IgM- and IgG-positive immunocompetent cells were present in the subepithelial layers of the organs observed in our study. This study indicates that IgM, present in mucosal surfaces, derived from an active secretion, as well as secretory IgA, whereas most of the IgG present in the human seminal plasma were probably due to transudation process. Immunoreactivity for IgG in the vesical and pelvic epithelia could depend upon to virus-specific IgG antibodies produced by the mucosa. This in turn can contribute to the total antiviral activity in mucosal secretions. SN - 1122-6714 UR - https://www.unboundmedicine.com/medline/citation/11315953/Immunoglobulins_in_the_human_male_genitourinary_tract_ DB - PRIME DP - Unbound Medicine ER -