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Interferon therapy in hemodialysis patients with chronic hepatitis C virus infection induces a high rate of long-term sustained virological and biochemical response.
Clin Nephrol. 2001 Mar; 55(3):220-6.CN

Abstract

AIM

The aim of the present study was to analyze the efficacy and tolerance of interferon (IFN) therapy in hemodialysis (HD) patients with chronic hepatitis C virus (HCV) infection. Specifically, we assessed whether the "normalization" of serum ALT levels was associated with the disappearance of the HCV-RNA.

METHODS

Thirteen hemodialysis patients with chronic hepatitis C were treated for one year with 3 MU of alpha-IFN. The primary end point was a sustained virological response defined as the absence of HCV-RNA in the last follow-up; the secondary end points were normalization of the serum ALT levels and histological improvement. ALT was considered "normal" below 27 IU/l.

RESULTS

Ten patients completed the treatment, which was discontinued in the other 3 (23%). By the end of the treatment a virological response was observed in 8 of the 10 patients (80%) who completed the one-year IFN therapy. Biochemical response was associated with a virological response in 8 of the 9 patients in whom ALT levels became normal. Three patients had a biochemical and virological relapse in the follow-up. Two of them received a further year of IFN therapy, which resulted in a sustained biochemical and virological response. In all patients who underwent a liver biopsy (n = 5), the inflammation score improved. After a median follow-up of 5 years (range 2 - 7), a sustained response was observed in 6 (46%) of the 13 patients enrolled. Two patients with a sustained response received a kidney transplant and after more than 6 years still maintain a biochemical and virological response. Side effects included flu-like syndrome (n = 8), hemoglobin decrease (n = 8), thrombocytopenia (n = 3), depression (n = 1) and seizures (n = 1).

CONCLUSION

IFN treatment over a one-year period produces a high rate of long-term virological response in HD patients, associated to a biochemical response in all cases.

Authors+Show Affiliations

Servicios de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain. mespinosah@medynet.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

11316242

Citation

Espinosa, M, et al. "Interferon Therapy in Hemodialysis Patients With Chronic Hepatitis C Virus Infection Induces a High Rate of Long-term Sustained Virological and Biochemical Response." Clinical Nephrology, vol. 55, no. 3, 2001, pp. 220-6.
Espinosa M, Rodriguez M, Martin-Malo A, et al. Interferon therapy in hemodialysis patients with chronic hepatitis C virus infection induces a high rate of long-term sustained virological and biochemical response. Clin Nephrol. 2001;55(3):220-6.
Espinosa, M., Rodriguez, M., Martin-Malo, A., Alvarez de Lara, M. A., Gonzalez, R., Lopez-Rubio, F., de la Mata, M., & Aljama, P. (2001). Interferon therapy in hemodialysis patients with chronic hepatitis C virus infection induces a high rate of long-term sustained virological and biochemical response. Clinical Nephrology, 55(3), 220-6.
Espinosa M, et al. Interferon Therapy in Hemodialysis Patients With Chronic Hepatitis C Virus Infection Induces a High Rate of Long-term Sustained Virological and Biochemical Response. Clin Nephrol. 2001;55(3):220-6. PubMed PMID: 11316242.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interferon therapy in hemodialysis patients with chronic hepatitis C virus infection induces a high rate of long-term sustained virological and biochemical response. AU - Espinosa,M, AU - Rodriguez,M, AU - Martin-Malo,A, AU - Alvarez de Lara,M A, AU - Gonzalez,R, AU - Lopez-Rubio,F, AU - de la Mata,M, AU - Aljama,P, PY - 2001/4/24/pubmed PY - 2001/7/28/medline PY - 2001/4/24/entrez SP - 220 EP - 6 JF - Clinical nephrology JO - Clin. Nephrol. VL - 55 IS - 3 N2 - AIM: The aim of the present study was to analyze the efficacy and tolerance of interferon (IFN) therapy in hemodialysis (HD) patients with chronic hepatitis C virus (HCV) infection. Specifically, we assessed whether the "normalization" of serum ALT levels was associated with the disappearance of the HCV-RNA. METHODS: Thirteen hemodialysis patients with chronic hepatitis C were treated for one year with 3 MU of alpha-IFN. The primary end point was a sustained virological response defined as the absence of HCV-RNA in the last follow-up; the secondary end points were normalization of the serum ALT levels and histological improvement. ALT was considered "normal" below 27 IU/l. RESULTS: Ten patients completed the treatment, which was discontinued in the other 3 (23%). By the end of the treatment a virological response was observed in 8 of the 10 patients (80%) who completed the one-year IFN therapy. Biochemical response was associated with a virological response in 8 of the 9 patients in whom ALT levels became normal. Three patients had a biochemical and virological relapse in the follow-up. Two of them received a further year of IFN therapy, which resulted in a sustained biochemical and virological response. In all patients who underwent a liver biopsy (n = 5), the inflammation score improved. After a median follow-up of 5 years (range 2 - 7), a sustained response was observed in 6 (46%) of the 13 patients enrolled. Two patients with a sustained response received a kidney transplant and after more than 6 years still maintain a biochemical and virological response. Side effects included flu-like syndrome (n = 8), hemoglobin decrease (n = 8), thrombocytopenia (n = 3), depression (n = 1) and seizures (n = 1). CONCLUSION: IFN treatment over a one-year period produces a high rate of long-term virological response in HD patients, associated to a biochemical response in all cases. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/11316242/Interferon_therapy_in_hemodialysis_patients_with_chronic_hepatitis_C_virus_infection_induces_a_high_rate_of_long_term_sustained_virological_and_biochemical_response_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -