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[Methylprednisolone-induced acute generalized exanthematous pustulosis].
Ann Dermatol Venereol. 2001 Mar; 128(3 Pt 1):241-3.AD

Abstract

BACKGROUND

Acute generalized exanthematous pustulosis is a rare drug allergy. Generalized reactions to systematically administrated corticosteroids are even rarer. We report the first case of acute generalized exanthematous pustulosis due to methylprednisolone.

CASE REPORT

A thirty year-old-woman presented, a few hours after intravenous administration of methylprednisolone indicated for multiple sclerosis, a maculopapulous rash predominant in the folds rapidly becoming pustulous with malaise, fever and neutrophilia. The histologic examination and negativity of microbiological cultures were consistent with the diagnostic of acute generalized exanthematous pustulosis. The rash cleared spontaneously in one week with normalization of the biology. One month later, epicutaneous tests, confirmed the allergy to group A corticosteroids. The treatment of multiple sclerosis was pursued with dexamethasone.

DISCUSSION

Clinical and histological manifestations were consistent with the diagnostic of acute generalized exanthematous pustulosis to methylprednisolone. Generalized reaction to systematically administered corticosteroids are very rare. Immediate reactions are the most frequently reported reactions, only about thirty delayed-type generalized skin eruptions have been reported to date. Group A corticosteroids are the most frequent causal agent. Epicutaneous tests have good sensitivity for acute generalized exanthematous pustulosis, for allergy to corticosteroids, delayed results are very important.

Authors+Show Affiliations

Mussot-Chia C
Services de Médecine Interne et de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris.
Flechet ML
No affiliation info available
Napolitano M
No affiliation info available
Herson S
No affiliation info available
Frances C
No affiliation info available
Chosidow O
No affiliation info available

MeSH

Acute DiseaseAdultDrug EruptionsExanthemaFemaleGlucocorticoidsHumansMethylprednisoloneSkin Diseases, Vesiculobullous

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

fre

PubMed ID

11319388

Citation

Mussot-Chia, C, et al. "[Methylprednisolone-induced Acute Generalized Exanthematous Pustulosis]." Annales De Dermatologie Et De Venereologie, vol. 128, no. 3 Pt 1, 2001, pp. 241-3.
Mussot-Chia C, Flechet ML, Napolitano M, et al. [Methylprednisolone-induced acute generalized exanthematous pustulosis]. Ann Dermatol Venereol. 2001;128(3 Pt 1):241-3.
Mussot-Chia, C., Flechet, M. L., Napolitano, M., Herson, S., Frances, C., & Chosidow, O. (2001). [Methylprednisolone-induced acute generalized exanthematous pustulosis]. Annales De Dermatologie Et De Venereologie, 128(3 Pt 1), 241-3.
Mussot-Chia C, et al. [Methylprednisolone-induced Acute Generalized Exanthematous Pustulosis]. Ann Dermatol Venereol. 2001;128(3 Pt 1):241-3. PubMed PMID: 11319388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Methylprednisolone-induced acute generalized exanthematous pustulosis]. AU - Mussot-Chia,C, AU - Flechet,M L, AU - Napolitano,M, AU - Herson,S, AU - Frances,C, AU - Chosidow,O, PY - 2001/4/25/pubmed PY - 2001/8/31/medline PY - 2001/4/25/entrez SP - 241 EP - 3 JF - Annales de dermatologie et de venereologie JO - Ann Dermatol Venereol VL - 128 IS - 3 Pt 1 N2 - BACKGROUND: Acute generalized exanthematous pustulosis is a rare drug allergy. Generalized reactions to systematically administrated corticosteroids are even rarer. We report the first case of acute generalized exanthematous pustulosis due to methylprednisolone. CASE REPORT: A thirty year-old-woman presented, a few hours after intravenous administration of methylprednisolone indicated for multiple sclerosis, a maculopapulous rash predominant in the folds rapidly becoming pustulous with malaise, fever and neutrophilia. The histologic examination and negativity of microbiological cultures were consistent with the diagnostic of acute generalized exanthematous pustulosis. The rash cleared spontaneously in one week with normalization of the biology. One month later, epicutaneous tests, confirmed the allergy to group A corticosteroids. The treatment of multiple sclerosis was pursued with dexamethasone. DISCUSSION: Clinical and histological manifestations were consistent with the diagnostic of acute generalized exanthematous pustulosis to methylprednisolone. Generalized reaction to systematically administered corticosteroids are very rare. Immediate reactions are the most frequently reported reactions, only about thirty delayed-type generalized skin eruptions have been reported to date. Group A corticosteroids are the most frequent causal agent. Epicutaneous tests have good sensitivity for acute generalized exanthematous pustulosis, for allergy to corticosteroids, delayed results are very important. SN - 0151-9638 UR - https://www.unboundmedicine.com/medline/citation/11319388/[Methylprednisolone_induced_acute_generalized_exanthematous_pustulosis]_ DB - PRIME DP - Unbound Medicine ER -