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[Are rheological markers of poor prognosis present in diabetic arteriopathies?].
J Mal Vasc. 2001 Apr; 26(2):117-21.JM

Abstract

One of the traits of type I and II diabetes lies in the presence of extensive rheological disorders. Rheological changes appear during infancy, mainly in type I diabetes: decreased red cell deformability, leukocyte rigidity, monocyte activation, alteration in microvessel flux (sludge) and functions. Such disorders are however sensitive to insulin and metabolic correction for a long period. Macrorheological disorders develop at the time of puberty and when lipid changes and vascular complications appear (hypertension, visceral obesity, atherosclerosis). Such changes have potent effects on diabetic arteriopathy, as shown by altered TcPO(2). Numerous medical teams are taking into account red cell aggregation measurements reflecting post-capillary flux behavior. In addition, a proposed score may be used based on fibrinogen, hematocrit, triglycerides as viscosity acting factors, and endothelial markers, Willebrand factor and VCAM-1. An increased score is an indication of suspected distal functional alteration of microvessels.

Authors+Show Affiliations

Laboratoire Universitaire d'Hématologie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex.

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

11319417

Citation

Boisseau, M R.. "[Are Rheological Markers of Poor Prognosis Present in Diabetic Arteriopathies?]." Journal Des Maladies Vasculaires, vol. 26, no. 2, 2001, pp. 117-21.
Boisseau MR. [Are rheological markers of poor prognosis present in diabetic arteriopathies?]. J Mal Vasc. 2001;26(2):117-21.
Boisseau, M. R. (2001). [Are rheological markers of poor prognosis present in diabetic arteriopathies?]. Journal Des Maladies Vasculaires, 26(2), 117-21.
Boisseau MR. [Are Rheological Markers of Poor Prognosis Present in Diabetic Arteriopathies?]. J Mal Vasc. 2001;26(2):117-21. PubMed PMID: 11319417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Are rheological markers of poor prognosis present in diabetic arteriopathies?]. A1 - Boisseau,M R, PY - 2001/4/25/pubmed PY - 2001/6/29/medline PY - 2001/4/25/entrez SP - 117 EP - 21 JF - Journal des maladies vasculaires JO - J Mal Vasc VL - 26 IS - 2 N2 - One of the traits of type I and II diabetes lies in the presence of extensive rheological disorders. Rheological changes appear during infancy, mainly in type I diabetes: decreased red cell deformability, leukocyte rigidity, monocyte activation, alteration in microvessel flux (sludge) and functions. Such disorders are however sensitive to insulin and metabolic correction for a long period. Macrorheological disorders develop at the time of puberty and when lipid changes and vascular complications appear (hypertension, visceral obesity, atherosclerosis). Such changes have potent effects on diabetic arteriopathy, as shown by altered TcPO(2). Numerous medical teams are taking into account red cell aggregation measurements reflecting post-capillary flux behavior. In addition, a proposed score may be used based on fibrinogen, hematocrit, triglycerides as viscosity acting factors, and endothelial markers, Willebrand factor and VCAM-1. An increased score is an indication of suspected distal functional alteration of microvessels. SN - 0398-0499 UR - https://www.unboundmedicine.com/medline/citation/11319417/[Are_rheological_markers_of_poor_prognosis_present_in_diabetic_arteriopathies]_ L2 - http://www.em-consulte.com/retrieve/pii/69292 DB - PRIME DP - Unbound Medicine ER -