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Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy.
J Infect Dis. 2001 May 15; 183(10):1522-5.JI

Abstract

A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels.

Authors+Show Affiliations

Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11319689

Citation

Wellons, M F., et al. "Immunologic Profile of Human Immunodeficiency Virus-infected Patients During Viral Remission and Relapse On Antiretroviral Therapy." The Journal of Infectious Diseases, vol. 183, no. 10, 2001, pp. 1522-5.
Wellons MF, Ottinger JS, Weinhold KJ, et al. Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. J Infect Dis. 2001;183(10):1522-5.
Wellons, M. F., Ottinger, J. S., Weinhold, K. J., Gryszowka, V., Sanders, L. L., Edwards, L. J., Gooding, M. E., Thomasch, J. R., & Bartlett, J. A. (2001). Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. The Journal of Infectious Diseases, 183(10), 1522-5.
Wellons MF, et al. Immunologic Profile of Human Immunodeficiency Virus-infected Patients During Viral Remission and Relapse On Antiretroviral Therapy. J Infect Dis. 2001 May 15;183(10):1522-5. PubMed PMID: 11319689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunologic profile of human immunodeficiency virus-infected patients during viral remission and relapse on antiretroviral therapy. AU - Wellons,M F, AU - Ottinger,J S, AU - Weinhold,K J, AU - Gryszowka,V, AU - Sanders,L L, AU - Edwards,L J, AU - Gooding,M E, AU - Thomasch,J R, AU - Bartlett,J A, Y1 - 2001/04/17/ PY - 2000/09/21/received PY - 2001/02/20/revised PY - 2001/4/25/pubmed PY - 2001/6/15/medline PY - 2001/4/25/entrez SP - 1522 EP - 5 JF - The Journal of infectious diseases JO - J Infect Dis VL - 183 IS - 10 N2 - A dissociation between plasma human immunodeficiency virus (HIV) RNA levels and CD4(+) cell counts has been reported in patients experiencing viral relapse while receiving antiretroviral therapy. This study compared patients with stable CD4(+) lymphocytes during viral relapse while receiving treatment with patients who had sustained virus suppression. Plasma HIV RNA levels, lymphocyte immunophenotyping, and T cell receptor excision circle (TREC) levels were measured. Naive CD4(+) lymphocyte phenotype and TREC levels were not significantly different in patients with virus suppression or in those who had relapsed. However, CD8(+) lymphocyte activation, including the number and percentage of activated cells and CD38 antibody-binding capacity, was significantly elevated during viral relapse, compared with that in suppressed patients. By multivariable regression analyses, CD8(+) and CD4(+) lymphocyte activation were associated significantly with increasing plasma HIV RNA levels. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11319689/Immunologic_profile_of_human_immunodeficiency_virus_infected_patients_during_viral_remission_and_relapse_on_antiretroviral_therapy_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/320193 DB - PRIME DP - Unbound Medicine ER -