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High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.
J Infect Dis. 2001 May 15; 183(10):1535-8.JI

Abstract

Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance.

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Authors+Show Affiliations

Babiker HA
Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, Scotland, United Kingdom. H.Babiker@ed.ac.uk
Pringle SJ
No affiliation info available
Abdel-Muhsin A
No affiliation info available
Mackinnon M
No affiliation info available
Hunt P
No affiliation info available
Walliker D
No affiliation info available

MeSH

ATP-Binding Cassette TransportersAllelesAnimalsAntimalarialsChloroquineClone CellsDrug ResistanceGenes, ProtozoanHumansLinkage DisequilibriumMalaria, FalciparumMembrane ProteinsMembrane Transport ProteinsMutationParasitic Sensitivity TestsPlasmodium falciparumPolymorphism, GeneticProtozoan ProteinsSudan

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11319692

Citation

Babiker, H A., et al. "High-level Chloroquine Resistance in Sudanese Isolates of Plasmodium Falciparum Is Associated With Mutations in the Chloroquine Resistance Transporter Gene Pfcrt and the Multidrug Resistance Gene Pfmdr1." The Journal of Infectious Diseases, vol. 183, no. 10, 2001, pp. 1535-8.
Babiker HA, Pringle SJ, Abdel-Muhsin A, et al. High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. J Infect Dis. 2001;183(10):1535-8.
Babiker, H. A., Pringle, S. J., Abdel-Muhsin, A., Mackinnon, M., Hunt, P., & Walliker, D. (2001). High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. The Journal of Infectious Diseases, 183(10), 1535-8.
Babiker HA, et al. High-level Chloroquine Resistance in Sudanese Isolates of Plasmodium Falciparum Is Associated With Mutations in the Chloroquine Resistance Transporter Gene Pfcrt and the Multidrug Resistance Gene Pfmdr1. J Infect Dis. 2001 May 15;183(10):1535-8. PubMed PMID: 11319692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1. AU - Babiker,H A, AU - Pringle,S J, AU - Abdel-Muhsin,A, AU - Mackinnon,M, AU - Hunt,P, AU - Walliker,D, Y1 - 2001/04/13/ PY - 2000/11/02/received PY - 2001/02/12/revised PY - 2001/4/25/pubmed PY - 2001/6/15/medline PY - 2001/4/25/entrez SP - 1535 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 183 IS - 10 N2 - Polymorphisms were examined in 2 Plasmodium falciparum genes, as were chloroquine responses of clones and isolates from a village in eastern Sudan. There was a significant association between an allele of the P. falciparum chloroquine resistance transporter gene (pfcrt-T76) and both in vitro and in vivo resistance. There was a less significant association with the multidrug resistance gene pfmdr1-Y86 allele. A significant association between pfmdr1-Y86 and pfcrt-T76 was apparent among resistant isolates, which suggests a joint action of the 2 genes in high-level chloroquine resistance. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/11319692/High_level_chloroquine_resistance_in_Sudanese_isolates_of_Plasmodium_falciparum_is_associated_with_mutations_in_the_chloroquine_resistance_transporter_gene_pfcrt_and_the_multidrug_resistance_Gene_pfmdr1_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/320195 DB - PRIME DP - Unbound Medicine ER -