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Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1.
Genes Chromosomes Cancer. 2001 Jun; 31(2):172-81.GC

Abstract

Deletions in the short arm of chromosome 1 (1p36) and MYCN amplification are common in neuroblastoma. Previously we showed evidence of at least two different neuroblastoma tumor-suppressor loci on 1p. One is associated with MYCN single-copy tumors and maps distal on 1p36.3. A second, more proximal locus maps to 1p36.1 and is deleted in about 90% of neuroblastomas with MYCN amplification. The cell line UHG-NP has the smallest 1p36 deletion of all neuroblastoma cell lines with MYCN amplifications. We assume that the more proximal locus maps within this deletion, close to its proximal border. Here we present the exact localization of the 1p deletion breakpoint of UHG-NP. A 600-kb PAC contig spanning the breakpoint was analyzed for genes and aberrations. Two more neuroblastoma-associated aberrations were mapped within 150 kb of the UHG-NP breakpoint. Within the contig, we identified nine genes expressed in neuroblastoma cells. One of these genes, AML2, maps 200 kb distal to the UHG-NP breakpoint but is expressed only rarely in neuroblastoma and showed no mutations.

Authors+Show Affiliations

Department of Human Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11319804

Citation

Spieker, N, et al. "Three Chromosomal Rearrangements in Neuroblastoma Cluster Within a 300-kb Region On 1p36.1." Genes, Chromosomes & Cancer, vol. 31, no. 2, 2001, pp. 172-81.
Spieker N, Beitsma M, Van Sluis P, et al. Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1. Genes Chromosomes Cancer. 2001;31(2):172-81.
Spieker, N., Beitsma, M., Van Sluis, P., Chan, A., Caron, H., & Versteeg, R. (2001). Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1. Genes, Chromosomes & Cancer, 31(2), 172-81.
Spieker N, et al. Three Chromosomal Rearrangements in Neuroblastoma Cluster Within a 300-kb Region On 1p36.1. Genes Chromosomes Cancer. 2001;31(2):172-81. PubMed PMID: 11319804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Three chromosomal rearrangements in neuroblastoma cluster within a 300-kb region on 1p36.1. AU - Spieker,N, AU - Beitsma,M, AU - Van Sluis,P, AU - Chan,A, AU - Caron,H, AU - Versteeg,R, PY - 2001/4/25/pubmed PY - 2001/7/13/medline PY - 2001/4/25/entrez SP - 172 EP - 81 JF - Genes, chromosomes & cancer JO - Genes Chromosomes Cancer VL - 31 IS - 2 N2 - Deletions in the short arm of chromosome 1 (1p36) and MYCN amplification are common in neuroblastoma. Previously we showed evidence of at least two different neuroblastoma tumor-suppressor loci on 1p. One is associated with MYCN single-copy tumors and maps distal on 1p36.3. A second, more proximal locus maps to 1p36.1 and is deleted in about 90% of neuroblastomas with MYCN amplification. The cell line UHG-NP has the smallest 1p36 deletion of all neuroblastoma cell lines with MYCN amplifications. We assume that the more proximal locus maps within this deletion, close to its proximal border. Here we present the exact localization of the 1p deletion breakpoint of UHG-NP. A 600-kb PAC contig spanning the breakpoint was analyzed for genes and aberrations. Two more neuroblastoma-associated aberrations were mapped within 150 kb of the UHG-NP breakpoint. Within the contig, we identified nine genes expressed in neuroblastoma cells. One of these genes, AML2, maps 200 kb distal to the UHG-NP breakpoint but is expressed only rarely in neuroblastoma and showed no mutations. SN - 1045-2257 UR - https://www.unboundmedicine.com/medline/citation/11319804/Three_chromosomal_rearrangements_in_neuroblastoma_cluster_within_a_300_kb_region_on_1p36_1_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1045-2257&date=2001&volume=31&issue=2&spage=172 DB - PRIME DP - Unbound Medicine ER -