Tags

Type your tag names separated by a space and hit enter

Increased CSF cortisol in AD is a function of APOE genotype.
Neurology 2001; 56(8):1094-8Neur

Abstract

BACKGROUND

Increased hypothalamic-pituitary-adrenal (HPA) axis activity manifested by elevated cortisol levels is observed in AD and may contribute to AD by lowering the threshold for neuronal degeneration. Presence of the APOE-epsilon4 allele increases risk for AD. Increased cortisol concentrations in apoE-deficient mice suggest that APOE genotype may influence cortisol concentrations in AD.

METHODS

The authors measured cortisol levels in CSF and determined APOE genotypes for 64 subjects with AD and 34 nondemented older control subjects.

RESULTS

CSF cortisol was significantly higher in AD than in control subjects. CSF cortisol concentrations differed with respect to APOE genotype in both subjects with AD (epsilon4/epsilon4 > epsilon3/4epsilon > epsilon3/epsilon3) and normal older control subjects (epsilon3/epsilon4 > epsilon3/epsilon3 > epsilon2/epsilon3). Comparison of CSF cortisol concentrations within the epsilon3/epsilon4 and epsilon3/epsilon3 genotypes revealed no differences between AD and control subject groups.

CONCLUSIONS

Higher CSF cortisol concentrations were associated with increased frequency of the APOE-epsilon4 allele and decreased frequency of the APOE-epsilon2 allele in AD subjects relative to control subjects. This effect of APOE genotype on HPA axis activity may be related to the increased risk for AD in persons carrying the APOE-epsilon4 allele and decreased risk for AD in persons carrying the APOE-epsilon2 allele.

Authors+Show Affiliations

Mental Illness Research, Education, and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA 98108, USA. peskind.elaine@seattle.va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

11320185

Citation

Peskind, E R., et al. "Increased CSF Cortisol in AD Is a Function of APOE Genotype." Neurology, vol. 56, no. 8, 2001, pp. 1094-8.
Peskind ER, Wilkinson CW, Petrie EC, et al. Increased CSF cortisol in AD is a function of APOE genotype. Neurology. 2001;56(8):1094-8.
Peskind, E. R., Wilkinson, C. W., Petrie, E. C., Schellenberg, G. D., & Raskind, M. A. (2001). Increased CSF cortisol in AD is a function of APOE genotype. Neurology, 56(8), pp. 1094-8.
Peskind ER, et al. Increased CSF Cortisol in AD Is a Function of APOE Genotype. Neurology. 2001 Apr 24;56(8):1094-8. PubMed PMID: 11320185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased CSF cortisol in AD is a function of APOE genotype. AU - Peskind,E R, AU - Wilkinson,C W, AU - Petrie,E C, AU - Schellenberg,G D, AU - Raskind,M A, PY - 2001/4/26/pubmed PY - 2001/5/26/medline PY - 2001/4/26/entrez SP - 1094 EP - 8 JF - Neurology JO - Neurology VL - 56 IS - 8 N2 - BACKGROUND: Increased hypothalamic-pituitary-adrenal (HPA) axis activity manifested by elevated cortisol levels is observed in AD and may contribute to AD by lowering the threshold for neuronal degeneration. Presence of the APOE-epsilon4 allele increases risk for AD. Increased cortisol concentrations in apoE-deficient mice suggest that APOE genotype may influence cortisol concentrations in AD. METHODS: The authors measured cortisol levels in CSF and determined APOE genotypes for 64 subjects with AD and 34 nondemented older control subjects. RESULTS: CSF cortisol was significantly higher in AD than in control subjects. CSF cortisol concentrations differed with respect to APOE genotype in both subjects with AD (epsilon4/epsilon4 > epsilon3/4epsilon > epsilon3/epsilon3) and normal older control subjects (epsilon3/epsilon4 > epsilon3/epsilon3 > epsilon2/epsilon3). Comparison of CSF cortisol concentrations within the epsilon3/epsilon4 and epsilon3/epsilon3 genotypes revealed no differences between AD and control subject groups. CONCLUSIONS: Higher CSF cortisol concentrations were associated with increased frequency of the APOE-epsilon4 allele and decreased frequency of the APOE-epsilon2 allele in AD subjects relative to control subjects. This effect of APOE genotype on HPA axis activity may be related to the increased risk for AD in persons carrying the APOE-epsilon4 allele and decreased risk for AD in persons carrying the APOE-epsilon2 allele. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/11320185/Increased_CSF_cortisol_in_AD_is_a_function_of_APOE_genotype_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=11320185 DB - PRIME DP - Unbound Medicine ER -