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Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts.
Clin Hemorheol Microcirc. 2000; 23(2-4):177-83.CH

Abstract

The immunostimulating effect of "Pule" (Alstonia scholaris (L.) R.Br., Apocynaceae) bark extracts was studied in BALB/c mouse. The extracts were administered orally, once a day for 7 consecutive days. The results showed that at the same doses (50, 100 and 200 mg/kg b.w.) the aqueous extract had higher phagocytic index (1.39-1.79) than the ethanolic extracts (0.81-0.93) in normal mice. The aqueous extract at 50 mg/kg b.w. also enhanced phagocytic activity of immunosuppressed mice significantly (P < 0.01). At 50 and 100 mg/kg b.w. the extract prevents the decrease of immune system induced by prednisone. The aqueous extract at 100 mg/kg b.w. increased lytic activity of peritoneal exudate cells against Escherichia coli significantly (P < 0.05). At the doses of 50 and 100 mg/kg b.w. the aqueous extract had no effect on primary antibody level. The aqueous extract at 50 mg/kg b.w. induced the cellular immune response while at 100 mg/kg b.w. inhibited the delayed type of hypersensitivity reaction.

Authors+Show Affiliations

Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Ganesa, Indonesia. immaiwo@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11321438

Citation

Iwo, M I., et al. "Immunostimulating Effect of Pule (Alstonia Scholaris L. R.Br., Apocynaceae) Bark Extracts." Clinical Hemorheology and Microcirculation, vol. 23, no. 2-4, 2000, pp. 177-83.
Iwo MI, Soemardji AA, Retnoningrum DS, et al. Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts. Clin Hemorheol Microcirc. 2000;23(2-4):177-83.
Iwo, M. I., Soemardji, A. A., Retnoningrum, D. S., Sukrasno, ., & U, U. M. (2000). Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts. Clinical Hemorheology and Microcirculation, 23(2-4), 177-83.
Iwo MI, et al. Immunostimulating Effect of Pule (Alstonia Scholaris L. R.Br., Apocynaceae) Bark Extracts. Clin Hemorheol Microcirc. 2000;23(2-4):177-83. PubMed PMID: 11321438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunostimulating effect of pule (Alstonia scholaris L. R.Br., Apocynaceae) bark extracts. AU - Iwo,M I, AU - Soemardji,A A, AU - Retnoningrum,D S, AU - Sukrasno,, AU - U,U M, PY - 2001/4/26/pubmed PY - 2001/9/14/medline PY - 2001/4/26/entrez SP - 177 EP - 83 JF - Clinical hemorheology and microcirculation JO - Clin Hemorheol Microcirc VL - 23 IS - 2-4 N2 - The immunostimulating effect of "Pule" (Alstonia scholaris (L.) R.Br., Apocynaceae) bark extracts was studied in BALB/c mouse. The extracts were administered orally, once a day for 7 consecutive days. The results showed that at the same doses (50, 100 and 200 mg/kg b.w.) the aqueous extract had higher phagocytic index (1.39-1.79) than the ethanolic extracts (0.81-0.93) in normal mice. The aqueous extract at 50 mg/kg b.w. also enhanced phagocytic activity of immunosuppressed mice significantly (P < 0.01). At 50 and 100 mg/kg b.w. the extract prevents the decrease of immune system induced by prednisone. The aqueous extract at 100 mg/kg b.w. increased lytic activity of peritoneal exudate cells against Escherichia coli significantly (P < 0.05). At the doses of 50 and 100 mg/kg b.w. the aqueous extract had no effect on primary antibody level. The aqueous extract at 50 mg/kg b.w. induced the cellular immune response while at 100 mg/kg b.w. inhibited the delayed type of hypersensitivity reaction. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/11321438/Immunostimulating_effect_of_pule__Alstonia_scholaris_L__R_Br__Apocynaceae__bark_extracts_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1386-0291&amp;volume=23&amp;issue=2-4&amp;spage=177 DB - PRIME DP - Unbound Medicine ER -