Tags

Type your tag names separated by a space and hit enter

Serum cytokine levels and antibody response to influenza vaccine in the elderly.

Abstract

Cytokines play critical roles in regulating the antibody response to vaccines. We sought to understand the role of endogenous cytokines in the determination of antibody production in the elderly, a group of subjects known to have a lower response rate to vaccination. We found that in a healthy elderly group, only 52% of whom responded to the influenza vaccine, endogenous levels of interleukin 6 (IL-6), IL-10 and gamma interferon (IFNgamma) did not differ statistically significantly between responders and non-responders (responders: n = 27, IL-6 = 293 +/- 101 pg/ml, IL-10 = 882 +/- 240 pg/ml; nonresponders: n = 26, IL-6 = 223 +/- 71 pg/ml, P = 0.57, IL-10 = 445 +/- 148 pg/ml, mean +/- SE, P = 0.14, respectively, and undetectable IFNgamma). Serum levels of these three cytokines were not changed significantly four weeks after vaccination (P < 0.05 for IL-6 and P < 0.01 for IL-10). In addition, there were also no age-dependent differences in serum IL-6 and IL-10 levels.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Dept of Molecular Biology and Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA.

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Antibodies, Viral
    Cytokines
    Enzyme-Linked Immunosorbent Assay
    Follow-Up Studies
    Hemagglutination Tests
    Humans
    Influenza A virus
    Influenza B virus
    Influenza Vaccines
    Interferon-gamma
    Interleukin-10
    Interleukin-6

    Pub Type(s)

    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    11322647

    Citation

    Krakauer, T, and C Russo. "Serum Cytokine Levels and Antibody Response to Influenza Vaccine in the Elderly." Immunopharmacology and Immunotoxicology, vol. 23, no. 1, 2001, pp. 35-41.
    Krakauer T, Russo C. Serum cytokine levels and antibody response to influenza vaccine in the elderly. Immunopharmacol Immunotoxicol. 2001;23(1):35-41.
    Krakauer, T., & Russo, C. (2001). Serum cytokine levels and antibody response to influenza vaccine in the elderly. Immunopharmacology and Immunotoxicology, 23(1), pp. 35-41.
    Krakauer T, Russo C. Serum Cytokine Levels and Antibody Response to Influenza Vaccine in the Elderly. Immunopharmacol Immunotoxicol. 2001;23(1):35-41. PubMed PMID: 11322647.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum cytokine levels and antibody response to influenza vaccine in the elderly. AU - Krakauer,T, AU - Russo,C, PY - 2001/4/27/pubmed PY - 2001/9/14/medline PY - 2001/4/27/entrez SP - 35 EP - 41 JF - Immunopharmacology and immunotoxicology JO - Immunopharmacol Immunotoxicol VL - 23 IS - 1 N2 - Cytokines play critical roles in regulating the antibody response to vaccines. We sought to understand the role of endogenous cytokines in the determination of antibody production in the elderly, a group of subjects known to have a lower response rate to vaccination. We found that in a healthy elderly group, only 52% of whom responded to the influenza vaccine, endogenous levels of interleukin 6 (IL-6), IL-10 and gamma interferon (IFNgamma) did not differ statistically significantly between responders and non-responders (responders: n = 27, IL-6 = 293 +/- 101 pg/ml, IL-10 = 882 +/- 240 pg/ml; nonresponders: n = 26, IL-6 = 223 +/- 71 pg/ml, P = 0.57, IL-10 = 445 +/- 148 pg/ml, mean +/- SE, P = 0.14, respectively, and undetectable IFNgamma). Serum levels of these three cytokines were not changed significantly four weeks after vaccination (P < 0.05 for IL-6 and P < 0.01 for IL-10). In addition, there were also no age-dependent differences in serum IL-6 and IL-10 levels. SN - 0892-3973 UR - https://www.unboundmedicine.com/medline/citation/11322647/Serum_cytokine_levels_and_antibody_response_to_influenza_vaccine_in_the_elderly_ L2 - http://www.tandfonline.com/doi/full/10.1081/IPH-100102565 DB - PRIME DP - Unbound Medicine ER -