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The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type.
J Clin Microbiol. 2001 May; 39(5):1932-7.JC

Abstract

Shiga toxin 2 (Stx2) has been reported as the main Shiga toxin associated with human disease. In addition, the Stx2 toxin type can have a profound impact on the degree of tissue damage in animal models. We have characterized the stx(2) subtype of 168 Shiga toxin-producing Escherichia coli (STEC) isolates of which 146 were derived from ovine sources (principally feces and meat) and 22 were isolated from humans. The ovine STEC isolates were of serotypes that have been shown to occur commonly in the gastrointestinal tract of healthy sheep. The major stx(2) subtype in the ovine isolates was shown to be stx(2d-Ount) (119 of 146 [81.5%]) and was predominantly associated with serotypes O75:H(-)/H8/H40, O91:H(-), O123:H(-), O128:H2, and OR:H2. However, 17 of 18 (94.4%) ovine isolates of serotype O5:H(-) possessed a stx(2d-O111/OX3a) subtype. Furthermore, STEC isolates of serotypes commonly found in sheep and recovered from both clinical and nonclinical human infections also contained a stx(2d) (stx(2d-Ount/O111/OX3a)) subtype. These studies suggest that a specific stx(2) subtype(s) associates with serotype and may have important epidemiological implications for tracing sources of E. coli during outbreaks of STEC-associated diseases in humans.

Authors+Show Affiliations

Elizabeth Macarthur Agricultural Institute, Camden, New South Wales 2570, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11326016

Citation

Ramachandran, V, et al. "The Common Ovine Shiga Toxin 2-containing Escherichia Coli Serotypes and Human Isolates of the Same Serotypes Possess a Stx2d Toxin Type." Journal of Clinical Microbiology, vol. 39, no. 5, 2001, pp. 1932-7.
Ramachandran V, Hornitzky MA, Bettelheim KA, et al. The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. J Clin Microbiol. 2001;39(5):1932-7.
Ramachandran, V., Hornitzky, M. A., Bettelheim, K. A., Walker, M. J., & Djordjevic, S. P. (2001). The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. Journal of Clinical Microbiology, 39(5), 1932-7.
Ramachandran V, et al. The Common Ovine Shiga Toxin 2-containing Escherichia Coli Serotypes and Human Isolates of the Same Serotypes Possess a Stx2d Toxin Type. J Clin Microbiol. 2001;39(5):1932-7. PubMed PMID: 11326016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The common ovine Shiga toxin 2-containing Escherichia coli serotypes and human isolates of the same serotypes possess a Stx2d toxin type. AU - Ramachandran,V, AU - Hornitzky,M A, AU - Bettelheim,K A, AU - Walker,M J, AU - Djordjevic,S P, PY - 2001/4/28/pubmed PY - 2001/8/17/medline PY - 2001/4/28/entrez SP - 1932 EP - 7 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 39 IS - 5 N2 - Shiga toxin 2 (Stx2) has been reported as the main Shiga toxin associated with human disease. In addition, the Stx2 toxin type can have a profound impact on the degree of tissue damage in animal models. We have characterized the stx(2) subtype of 168 Shiga toxin-producing Escherichia coli (STEC) isolates of which 146 were derived from ovine sources (principally feces and meat) and 22 were isolated from humans. The ovine STEC isolates were of serotypes that have been shown to occur commonly in the gastrointestinal tract of healthy sheep. The major stx(2) subtype in the ovine isolates was shown to be stx(2d-Ount) (119 of 146 [81.5%]) and was predominantly associated with serotypes O75:H(-)/H8/H40, O91:H(-), O123:H(-), O128:H2, and OR:H2. However, 17 of 18 (94.4%) ovine isolates of serotype O5:H(-) possessed a stx(2d-O111/OX3a) subtype. Furthermore, STEC isolates of serotypes commonly found in sheep and recovered from both clinical and nonclinical human infections also contained a stx(2d) (stx(2d-Ount/O111/OX3a)) subtype. These studies suggest that a specific stx(2) subtype(s) associates with serotype and may have important epidemiological implications for tracing sources of E. coli during outbreaks of STEC-associated diseases in humans. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/11326016/The_common_ovine_Shiga_toxin_2_containing_Escherichia_coli_serotypes_and_human_isolates_of_the_same_serotypes_possess_a_Stx2d_toxin_type_ L2 - https://journals.asm.org/doi/10.1128/JCM.39.5.1932-1937.2001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -