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Long term effect of highly selective vagotomy on basal and maximal acid output in man.
Gastroenterology. 1975 Jun; 68(6):1421-5.G

Abstract

Basal acid output (BAO) and Maximal acid outputs (MAO) were measured 5 years after highly selective vagotomy (HSV) in 21 patients who had previously undergone serial testing of BAO and MAO for up to 2 years after HSV. BAO was found to have decreased from a mean of 1.7 mEq per hr, 1 year after HSV, to 1.4 mEq per hr, 5 years after HSV (not significant). The mean reduction in BAO at 5 years, compared with the preoperative BAO of 8.4 mEq per hr, was 79%. The mean peak acid response to pentagastrin (PAO-Pg) increased from 20.2 mEq per hr at 1 year to 22.6 mEq per hr at 5 years (0.1 greater than P greater than 0.05). The mean reduction in PAO-Pg, compared with the preoperative PAO-Pg of 43 mEq per hr, was 51% at 1 year and 48% at 5 years. Inasmuch as acid outputs seem unlikely to increase further after 5 years, it is concluded that HSV produces a permanent reduction of about 80% in basal acid output and 50% in maximal acid output.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

1132624

Citation

Greenall, M J., et al. "Long Term Effect of Highly Selective Vagotomy On Basal and Maximal Acid Output in Man." Gastroenterology, vol. 68, no. 6, 1975, pp. 1421-5.
Greenall MJ, Lyndon PJ, Goligher JC, et al. Long term effect of highly selective vagotomy on basal and maximal acid output in man. Gastroenterology. 1975;68(6):1421-5.
Greenall, M. J., Lyndon, P. J., Goligher, J. C., & Johnston, D. (1975). Long term effect of highly selective vagotomy on basal and maximal acid output in man. Gastroenterology, 68(6), 1421-5.
Greenall MJ, et al. Long Term Effect of Highly Selective Vagotomy On Basal and Maximal Acid Output in Man. Gastroenterology. 1975;68(6):1421-5. PubMed PMID: 1132624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long term effect of highly selective vagotomy on basal and maximal acid output in man. AU - Greenall,M J, AU - Lyndon,P J, AU - Goligher,J C, AU - Johnston,D, PY - 1975/6/1/pubmed PY - 1975/6/1/medline PY - 1975/6/1/entrez SP - 1421 EP - 5 JF - Gastroenterology JO - Gastroenterology VL - 68 IS - 6 N2 - Basal acid output (BAO) and Maximal acid outputs (MAO) were measured 5 years after highly selective vagotomy (HSV) in 21 patients who had previously undergone serial testing of BAO and MAO for up to 2 years after HSV. BAO was found to have decreased from a mean of 1.7 mEq per hr, 1 year after HSV, to 1.4 mEq per hr, 5 years after HSV (not significant). The mean reduction in BAO at 5 years, compared with the preoperative BAO of 8.4 mEq per hr, was 79%. The mean peak acid response to pentagastrin (PAO-Pg) increased from 20.2 mEq per hr at 1 year to 22.6 mEq per hr at 5 years (0.1 greater than P greater than 0.05). The mean reduction in PAO-Pg, compared with the preoperative PAO-Pg of 43 mEq per hr, was 51% at 1 year and 48% at 5 years. Inasmuch as acid outputs seem unlikely to increase further after 5 years, it is concluded that HSV produces a permanent reduction of about 80% in basal acid output and 50% in maximal acid output. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1132624/Long_term_effect_of_highly_selective_vagotomy_on_basal_and_maximal_acid_output_in_man_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508575000960 DB - PRIME DP - Unbound Medicine ER -