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Relapses in leprosy patients treated with rifampicin plus dapsone after varying periods of dapsone monotherapy.
Indian J Lepr. 2001 Jan-Mar; 73(1):1-10.IJ

Abstract

Leprosy patients treated formerly with dapsone monotherapy followed by combined therapy with rifampicin plus dapsone were surveyed for relapse and rifampicin resistance. The relapse rate was significantly low for the 482 multibacillary (MB) patients receiving > 12 months combined therapy compared with the 49 MB cases receiving < 12 months of combined therapy. The relapse rate was related to the duration of dapsone monotherapy prior to combined therapy. The difference in relapse rate in 247 paucibacillary (PB) patients following > 12 months combined therapy was also of significance, compared with the 66 PB cases who had received < 12 months combined therapy. Five strains of M. leprae isolated from relapsed patients were sensitive to rifampicin by mouse foot-pad test and all relapsed patients responded favourably to fixed duration MDT regimen for MB cases.

Authors+Show Affiliations

Beijing Tropical Medicine Research Institute, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

11326592

Citation

Li, H Y., et al. "Relapses in Leprosy Patients Treated With Rifampicin Plus Dapsone After Varying Periods of Dapsone Monotherapy." Indian Journal of Leprosy, vol. 73, no. 1, 2001, pp. 1-10.
Li HY, Ran SP, Weng XM, et al. Relapses in leprosy patients treated with rifampicin plus dapsone after varying periods of dapsone monotherapy. Indian J Lepr. 2001;73(1):1-10.
Li, H. Y., Ran, S. P., Weng, X. M., Li, T. G., Deng, X. H., & Li, F. T. (2001). Relapses in leprosy patients treated with rifampicin plus dapsone after varying periods of dapsone monotherapy. Indian Journal of Leprosy, 73(1), 1-10.
Li HY, et al. Relapses in Leprosy Patients Treated With Rifampicin Plus Dapsone After Varying Periods of Dapsone Monotherapy. Indian J Lepr. 2001 Jan-Mar;73(1):1-10. PubMed PMID: 11326592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relapses in leprosy patients treated with rifampicin plus dapsone after varying periods of dapsone monotherapy. AU - Li,H Y, AU - Ran,S P, AU - Weng,X M, AU - Li,T G, AU - Deng,X H, AU - Li,F T, PY - 2001/5/1/pubmed PY - 2001/8/17/medline PY - 2001/5/1/entrez SP - 1 EP - 10 JF - Indian journal of leprosy JO - Indian J Lepr VL - 73 IS - 1 N2 - Leprosy patients treated formerly with dapsone monotherapy followed by combined therapy with rifampicin plus dapsone were surveyed for relapse and rifampicin resistance. The relapse rate was significantly low for the 482 multibacillary (MB) patients receiving > 12 months combined therapy compared with the 49 MB cases receiving < 12 months of combined therapy. The relapse rate was related to the duration of dapsone monotherapy prior to combined therapy. The difference in relapse rate in 247 paucibacillary (PB) patients following > 12 months combined therapy was also of significance, compared with the 66 PB cases who had received < 12 months combined therapy. Five strains of M. leprae isolated from relapsed patients were sensitive to rifampicin by mouse foot-pad test and all relapsed patients responded favourably to fixed duration MDT regimen for MB cases. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/11326592/Relapses_in_leprosy_patients_treated_with_rifampicin_plus_dapsone_after_varying_periods_of_dapsone_monotherapy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -