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[Expression of surfactant protein SP-A, SP-B, and SP-C mRNA in lungs of rats with bleomycin-induced pulmonary fibrosis].
Zhonghua Jie He He Hu Xi Za Zhi. 1998 Jul; 21(7):420-2.ZJ

Abstract

OBJECTIVE

The expressions of surfactant protein (SP)SP-A, SP-B, and SP-CmRNA in lungs of rats with bleomycin-induced pulmonary fibrosis were studied.

METHOD

A single dose of bleomycin(BLM) was intratracheal injected to induce pulmonary fibrosis of rats. Animals were killed at day 3, 7, 14 and 28 after BLM administration. The total RNA was extracted from the lung tissue. The expressions of SPsmRNA were analyzed with Northern blot.

RESULT

The number of alveolar type II epithelial cells increased in BLM-administered rats. The expressions of SP-A, SP-B and SP-CmRNA decreased at day 3 after BLM administration and decreased maximally at day 7, and then began to increase at day 14 and significantly increased at day 28, though they were still below the control levels.

CONCLUSION

The results show that the changes of expressions of SP-A, SP-B and SP-CmRNA occur during the development of bleomycin-induced pulmonary fibrosis in rats and they may play a role in the pathogenesis of lung fibrosis.

Authors+Show Affiliations

First Hospital of Beijing Medical University Beijing 100034.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11326882

Citation

Song, M, et al. "[Expression of Surfactant Protein SP-A, SP-B, and SP-C mRNA in Lungs of Rats With Bleomycin-induced Pulmonary Fibrosis]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 21, no. 7, 1998, pp. 420-2.
Song M, He B, Qiu Z. [Expression of surfactant protein SP-A, SP-B, and SP-C mRNA in lungs of rats with bleomycin-induced pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(7):420-2.
Song, M., He, B., & Qiu, Z. (1998). [Expression of surfactant protein SP-A, SP-B, and SP-C mRNA in lungs of rats with bleomycin-induced pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 21(7), 420-2.
Song M, He B, Qiu Z. [Expression of Surfactant Protein SP-A, SP-B, and SP-C mRNA in Lungs of Rats With Bleomycin-induced Pulmonary Fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(7):420-2. PubMed PMID: 11326882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of surfactant protein SP-A, SP-B, and SP-C mRNA in lungs of rats with bleomycin-induced pulmonary fibrosis]. AU - Song,M, AU - He,B, AU - Qiu,Z, PY - 2001/5/1/pubmed PY - 2001/6/15/medline PY - 2001/5/1/entrez SP - 420 EP - 2 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 21 IS - 7 N2 - OBJECTIVE: The expressions of surfactant protein (SP)SP-A, SP-B, and SP-CmRNA in lungs of rats with bleomycin-induced pulmonary fibrosis were studied. METHOD: A single dose of bleomycin(BLM) was intratracheal injected to induce pulmonary fibrosis of rats. Animals were killed at day 3, 7, 14 and 28 after BLM administration. The total RNA was extracted from the lung tissue. The expressions of SPsmRNA were analyzed with Northern blot. RESULT: The number of alveolar type II epithelial cells increased in BLM-administered rats. The expressions of SP-A, SP-B and SP-CmRNA decreased at day 3 after BLM administration and decreased maximally at day 7, and then began to increase at day 14 and significantly increased at day 28, though they were still below the control levels. CONCLUSION: The results show that the changes of expressions of SP-A, SP-B and SP-CmRNA occur during the development of bleomycin-induced pulmonary fibrosis in rats and they may play a role in the pathogenesis of lung fibrosis. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11326882/[Expression_of_surfactant_protein_SP_A_SP_B_and_SP_C_mRNA_in_lungs_of_rats_with_bleomycin_induced_pulmonary_fibrosis]_ L2 - https://medlineplus.gov/pulmonaryfibrosis.html DB - PRIME DP - Unbound Medicine ER -