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[Level of NCF and TNF-alpha in the BALF of ILD patients and their clinical significance].
Zhonghua Jie He He Hu Xi Za Zhi. 1998 May; 21(5):297-9.ZJ

Abstract

OBJECTIVE

To investigate the relationship between the level of the neutrophil chemotactic factor(NCF), tumor necrosis factor-alpha(TNF-alpha) in patients with interstitial lung disease(ILD) and the activity of ILD.

METHOD

The NCF activities in the BALF and in the serum from 11 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects were determined using the membrane filter and radio-immunoassay. The level of TNF-alpha was also detected.

RESULT

In the 7 IPF patients, the level of NCF and TNF-alpha (203 +/- 44 cells/10 HP, 11.7 +/- 2.9 ng/L) in the BALF was higher than that in 8 control patients (83 +/- 45 cells/10 HP, 6.5 +/- 1.4 ng/L, P < 0.01). The level of NCF and TNF-alpha in the BALF from 11 patients with sarcoidosis (186 +/- 50 cells/10 HP, 12 +/- 3 ng/L) was highet than those in 8 control patients (P < 0.01). The level of NCF and TNF-alpha in the BALF from patients with IPF was positive correlated with the percentage of neutrophil (NCF: r = 0.89, P < 0.01; TNF-alpha: r = 0.86, P < 0.05). The level of NCF and TNF-alpha in the BALF of patients with sarcoidosis was positive correlated with the percentage of lymphocyte (NCF: r = 0.78, P < 0.01; TNF-alpha: r = 0.73, P < 0.01.

CONCLUSION

The level of NCF and TNF-alpha in the BALF from patients with IPF and sarcoidosis can act as the marker of the activity of alveolitis of IPF and sarcoidosis.

Authors+Show Affiliations

Institute of the Respiratory Disease, China Medical University, Shenyang 110001.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

11326956

Citation

Chen, W, et al. "[Level of NCF and TNF-alpha in the BALF of ILD Patients and Their Clinical Significance]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 21, no. 5, 1998, pp. 297-9.
Chen W, Li Z, Hou X. [Level of NCF and TNF-alpha in the BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(5):297-9.
Chen, W., Li, Z., & Hou, X. (1998). [Level of NCF and TNF-alpha in the BALF of ILD patients and their clinical significance]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 21(5), 297-9.
Chen W, Li Z, Hou X. [Level of NCF and TNF-alpha in the BALF of ILD Patients and Their Clinical Significance]. Zhonghua Jie He He Hu Xi Za Zhi. 1998;21(5):297-9. PubMed PMID: 11326956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Level of NCF and TNF-alpha in the BALF of ILD patients and their clinical significance]. AU - Chen,W, AU - Li,Z, AU - Hou,X, PY - 2001/5/1/pubmed PY - 2001/6/15/medline PY - 2001/5/1/entrez SP - 297 EP - 9 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 21 IS - 5 N2 - OBJECTIVE: To investigate the relationship between the level of the neutrophil chemotactic factor(NCF), tumor necrosis factor-alpha(TNF-alpha) in patients with interstitial lung disease(ILD) and the activity of ILD. METHOD: The NCF activities in the BALF and in the serum from 11 patients with sarcoidosis, 7 with idiopathic pulmonary fibrosis (IPF) and 8 normal subjects were determined using the membrane filter and radio-immunoassay. The level of TNF-alpha was also detected. RESULT: In the 7 IPF patients, the level of NCF and TNF-alpha (203 +/- 44 cells/10 HP, 11.7 +/- 2.9 ng/L) in the BALF was higher than that in 8 control patients (83 +/- 45 cells/10 HP, 6.5 +/- 1.4 ng/L, P < 0.01). The level of NCF and TNF-alpha in the BALF from 11 patients with sarcoidosis (186 +/- 50 cells/10 HP, 12 +/- 3 ng/L) was highet than those in 8 control patients (P < 0.01). The level of NCF and TNF-alpha in the BALF from patients with IPF was positive correlated with the percentage of neutrophil (NCF: r = 0.89, P < 0.01; TNF-alpha: r = 0.86, P < 0.05). The level of NCF and TNF-alpha in the BALF of patients with sarcoidosis was positive correlated with the percentage of lymphocyte (NCF: r = 0.78, P < 0.01; TNF-alpha: r = 0.73, P < 0.01. CONCLUSION: The level of NCF and TNF-alpha in the BALF from patients with IPF and sarcoidosis can act as the marker of the activity of alveolitis of IPF and sarcoidosis. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/11326956/[Level_of_NCF_and_TNF_alpha_in_the_BALF_of_ILD_patients_and_their_clinical_significance]_ L2 - https://medlineplus.gov/pulmonaryfibrosis.html DB - PRIME DP - Unbound Medicine ER -